Results 71 to 80 of about 3,086,327 (347)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Variation in physiological host range in three strains of two species of the entomopathogenic fungus Beauveria [PDF]

open access: yes, 2018
Knowledge of the host range of a biocontrol agent (BCA) is fundamental. Host range determines the BCA's economic potential, as well as the possible risk for non-target organisms. Entomopathogenic fungal strains belonging to the genus Beauveria are widely
Besse, Samantha   +8 more
core   +2 more sources

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee   +9 more
wiley   +1 more source

Dynamic aging chain of the Czech Republic population

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
System dynamics is a method enabling simulation and subsequent analysis of various socio-economic problems. Even though it was founded about fifty years ago, it is relatively new and little used in the Czech Republic.
Igor Krejčí   +2 more
doaj   +1 more source

An approach to estimate the natural mortality rate in fish stocks [PDF]

open access: yes, 2003
A simple approach is introduced to estimate the natural mortality rate (M) of fish stocks. The approach is based on the age at maximum cohort biomass, or critical length (L*) concept.
Cubillos, L.A.
core  

The impact of antiretroviral therapy on adult mortality in rural Tanzania. [PDF]

open access: yes, 2012
OBJECTIVE: To describe the impact of antiretroviral therapy (ART) on mortality rates among adults participating in an HIV community cohort study in north-west Tanzania.
Changalucha, John   +12 more
core   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

Mortality Factors in Major Trauma Patients: Nation-wide Population-based Research in Taiwan

open access: yesInternational Journal of Gerontology, 2014
Background: Major trauma remains a significant medical concern, leading to about 10,000 deaths annually in Taiwan. Trauma system implementation has been shown to improve the outcomes in different countries.
Dorji Harnod   +4 more
doaj   +1 more source

Weight gain at 3 months of antiretroviral therapy is strongly associated with survival: evidence from two developing countries [PDF]

open access: yes, 2009
BACKGROUND: In developing countries, access to laboratory tests remains limited, and the use of simple tools such as weight to monitor HIV-infected patients treated with antiretroviral therapy should be evaluated.
Arnaud Fontanet   +33 more
core   +3 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

open access: yesMolecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova   +26 more
wiley   +1 more source

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