Results 71 to 80 of about 1,671,010 (304)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Effect of Parental Feeding on the Rate of Development and Mortality of Tribolium destructor Uyttenboorgaart (Coleoptera, Tenebrionidæ) [PDF]

, 1943
James M. Reynolds
openalex   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Mortalidade materna no Brasil: o que mostra a produção científica nos últimos 30 anos?

Cadernos de Saúde Pública
O objetivo deste trabalho foi descrever o perfil epidemiológico e a tendência da mortalidade materna no Brasil, por meio de revisão de estudos sobre o tema.
Marcia Lait Morse, Sandra Costa Fonseca, Mariane Doelinger Barbosa, Manuele Bonatto Calil, Fernanda Pinella Carvalhal Eyer   +4 more
doaj  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Ethephon Poisoning: Clinical Characteristics and Outcomes

Toxics
Ethephon (2-chloroethylphosphonic acid) is a generally used plant growth regulator, but the data on its toxic effects, especially in humans, are very limited.
Satariya Trakulsrichai, Kanokrat Chuayaupakarn, Phantakan Tansuwannarat, Panee Rittilert, Achara Tongpoo, Charuwan Sriapha, Winai Wananukul   +6 more
doaj   +1 more source

Dynamic aging chain of the Czech Republic population

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
System dynamics is a method enabling simulation and subsequent analysis of various socio-economic problems. Even though it was founded about fifty years ago, it is relatively new and little used in the Czech Republic.
Igor Krejčí, Romana Kvasnička, Jaroslav Švasta   +2 more
doaj   +1 more source

INDUCED CHANGES IN FEMALE GERM CELLS OF DROSOPHILA. III. THE EFFECTS OF MATERNAL DEHYDRATION ON OVIPOSITION RATE AND MORTALITY OF X-RAYED OOCYTES [PDF]

, 1957
Irwin H. Herskowitz
openalex   +1 more source