Results 61 to 70 of about 2,190,813 (317)

Untangling Effects of Human Disturbance and Natural Factors on Mortality Risk of Migratory Caribou

Frontiers in Ecology and Evolution, 2020
Human disturbances are rapidly increasing in northern and Arctic regions, raising concerns about the recovery and persistence of declining caribou (Rangifer tarandus) populations. Yet, the consequences of behavioral responses toward human disturbances on
Sabrina Plante, Sabrina Plante, Christian Dussault, Christian Dussault, Julien H. Richard, Julien H. Richard, Mathieu Garel, Steeve D. Côté, Steeve D. Côté   +8 more
doaj   +1 more source

Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 years of follow up [PDF]

, 1999
Objectives: To relate alcohol consumption to mortality. Design: Prospective cohort study. Setting: 27 workplaces in the west of Scotland. Participants: 5766 men aged 35-64 when screened in 1970-3 who answered questions on their usual weekly alcohol
V. M Hawthorne, Hole, D.J., Davey Smith, G., Hart, C.L., G. D. Smith, D. J Hole, Hawthorne, V.M., C. L Hart   +7 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mortality analysis of patients with acute coronary syndrome receiving comprehensive cardiac care (KOS-Zawal) during the COVID-19 pandemic period

Archives of Medical Science
Introduction Due to the SARS-CoV-2 pandemic, there have been fundamental changes to the delivery and operation of healthcare facilities across the world, significantly impacting how patients with a variety of diseases are treated.
Grzegorz Kubielas, Dorota Diakowska, Michał Czapla, Catherine Ross, Przemysław Mitkowski, Izabella Uchmanowicz   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Association between systemic immune-inflammation index and mortality in critically ill patients with chronic obstructive pulmonary disease: insights from the MIMIC-IV database

Frontiers in Medicine
BackgroundChronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality, particularly among critically ill patients. Despite the well-established role of inflammation in COPD pathogenesis, the prognostic significance of the ...
Mohan Giri, Anju Puri, Lan Huang, Shuliang Guo   +3 more
doaj   +1 more source

DNA methylation biomarker selected by an ensemble machine learning approach predicts mortality risk in an HIV-positive veteran population

Epigenetics, 2021
Background: With the improved life expectancy of people living with HIV (PLWH), identifying vulnerable subpopulations at high mortality risk is important.
Chang Shu, Amy C. Justice, Xinyu Zhang, Vincent C. Marconi, Dana B. Hancock, Eric O. Johnson, Ke Xu   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dementia Deaths Most Commonly Result from Heart and Lung Disease: Evidence from the South Carolina Alzheimer’s Disease Registry

Biomedicines
Background: Cardiovascular disease (CVD) significantly impacts Alzheimer’s Disease and Related Dementia (AD/ADRD) mortality. South Carolina has a high incidence of CVD and dementia mortality.
Daniel A. Amoatika, John R. Absher, Md Tareq Ferdous Khan, Maggi C. Miller   +3 more
doaj   +1 more source