Results 61 to 70 of about 42,215 (293)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

The Physicalist Worldview as Neurotic Ego-Defense Mechanism [PDF]

, 2016
The physicalist worldview is often portrayed as a dispassionate interpretation of reality motivated purely by observable facts. In this article, ideas of both depth and social psychology are used to show that this portrayal may not be accurate ...
Kastrup, Bernardo
core   +2 more sources

EFFECT OF MORTALITY SALIENCE ON HEALTH COMPROMISING BEHAVIOR

International Journal of Advanced Research, 2021
Over the decades, researchers have leaned on the TMT to explain numerous phenomena, including consumer choice, exercise motivation, risky driving behavior, and other behavioral domains. The present study aimed to investigate the effect of mortality salience on RSB as a health-compromising behavior. Sixty-two participants took part in the study. A quasi-
Paschal C. Onah, Daniel I. Omatalu
openaire   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Bodyweight Perceptions among Texas Women: The Effects of Religion, Race/Ethnicity, and Citizenship Status

, 2016
Despite previous work exploring linkages between religious participation and health, little research has looked at the role of religion in affecting bodyweight perceptions. Using the theoretical model developed by Levin et al.
Aida I. Ramos, Alan S Miller, Amy M Brausch, Amy M Burdette, Ana F Abraído-Lanza, Andrea K Henderson, Andrea L Ruiz, Andrea L. Ruiz, Bernice Dodor, Chris J Boyatzis, Christin New, Christopher G Ellision, Christopher G Ellison, Christopher G Ellison, Christopher G Ellison, David R Williams, Deborah Schooler, Eric A Finkelstein, Fenggang Yang, Gabriel A Acevedo, Gabriel A. Acevedo, Ginny Garcia, Harold Koenig, Heather Antecol, Ike S Okosun, Jacqueline A Pesa, Jeffrey S Levin, Jennifer A O’Dea, John B Dixon, John M Ruiz, John W Ayers, Joseph Martinez, Karen Hye-cheon Kim, Karen Hye-cheon Kim, Karen Hye-cheon Kim Yeary, Katya M Herman, Kirby K Reutter, KJ Lancaster, Krista M C Cline, Kristin Homan, Kristin J Flynn, Larry L Hunt, Lauren Rauscher, Linda M Chatters, Lisa M Bates, Lori A Klos, M Fogelholm, M Joy Jacobs-Pilipski, Marian L Fitzgibbon, Mark J DeHaven, Mark S Kaplan, Meg Lovejoy, Michael L Rowland, Mita Sanghavi Goel, Molly A Martin, Molly A Martin, Nancy D Brener, Neal Krause, Neal Krause, Neal Krause, Nicole M Overstreet, Penny Edgell, Philip B Mason, R Frank Gillum, R Khari Brown, Rashida R Dorsey, Rashida R Dorsey, Robert Joseph Taylor, Robert Wuthnow, Roy R Reeves, S Yaemsiri, Sahasporn Paeratakul, Scott Schieman, Seronda A Robinson, Shalonda E. B. Horton, Stephenie C Lemon, Tanya Nieri, Van Hook, Virginia W Chang, Wanda M Thompson, Winston Abara   +80 more
core   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, a highly robust N‐glycoproteomics (HRN) platform with a newly developed match‐between‐run scheme is used for biomarker discovery. This study proposes a protein‐centric strategy to prioritize proteins susceptible to aberrant glycosylation.
Lei Liu, Taiheng Ma, Qi Liu, He Zhu, Zheng Fang, Jiahong Ma, Ting Yu, Yan Wang, Jiahua Zhou, Xiaoyan Liu, Yaqian Li, Zhimou Guo, Xinmiao Liang, Mingming Dong, Deguang Sun, Mingliang Ye   +15 more
wiley   +1 more source

Abnormal resting-state functional connectivity in progressive supranuclear palsy and corticobasal syndrome [PDF]

, 2017
Background: Pathological and MRI-based evidence suggests that multiple brain structures are likely to be involved in functional disconnection between brain areas. Few studies have investigated resting-state functional connectivity (rsFC) in progressive
Berardelli, Alfredo, Bharti, Komal, Bologna, Matteo, Giannã¬, Costanza, Pantano, Patrizia, Petsas, Nikolaos, Piattella, Maria Cristina, Suppa, Antonio, Tona, Francesca, Upadhyay, Neeraj   +9 more
core   +2 more sources

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

The threat of COVID-19 will influence consumers’ taste compensation

Scientific Reports
This study examined how taste compensation is affected by mortality salience and its mechanisms during the pandemic. It conducted four studies and confirmed that mortality salience can cause consumers to seek stronger taste compensation, and the ...
Xin Yan, Xiong Yan, Xiaoying Huang, Linglan Zhao, Ying Liu   +4 more
doaj   +1 more source