Results 61 to 70 of about 8,327 (235)

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Deciphering the association between mortality salience and the “lying flat” movement: a social media analysis

Frontiers in Psychology
IntroductionWhen individuals face overwhelming situations, such as the heightened awareness of mortality triggered by the pandemic, they may adopt the “lying flat” response.
Jingyuan Zhu, Kaiyang Qin, Fangyuan Liu, Fangyuan Liu, Yue Hu, Hua Pang   +5 more
doaj   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Would you fancy a premium five o’clock after the funeral? Application of Terror Management Theory in daily shopping decisions

Acta Universitatis Lodziensis. Folia Psychologica, 2018
The present study has investigated how fear-of-death activation affected consumer food product choices. Undergraduate students (N = 130; Mage = 22.7; Meage = 21) differing on the conscious fear of death level participated in this study.
Radosław B. Walczak, Rafał Gerymski, Jakub Filipkowski   +2 more
doaj   +1 more source

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

The threat of COVID-19 will influence consumers’ taste compensation

Scientific Reports
This study examined how taste compensation is affected by mortality salience and its mechanisms during the pandemic. It conducted four studies and confirmed that mortality salience can cause consumers to seek stronger taste compensation, and the ...
Xin Yan, Xiong Yan, Xiaoying Huang, Linglan Zhao, Ying Liu   +4 more
doaj   +1 more source

Of Wealth and Death: Materialism, Mortality Salience, and Consumption Behavior [PDF]

Psychological Science, 2000
Theoretical work suggests that feelings of insecurity produce materialistic behavior, but most empirical evidence is correlational in nature. We therefore experimentally activated feelings of insecurity by having some subjects write short essays about death (mortality-salience condition).
T, Kasser, K M, Sheldon
openaire   +2 more sources

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Effectiveness of Attention Control Training on Attentional Bias Towards Death, Death Anxiety, and Sensitivity to Mortality Salience

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021
Background and Aim: Attention Control Training is a new cognitive intervention that improves emotion regulation by reducing attentional bias towards negative information.
Saeed Nasiri, Mohammad Noori, Maryam Aslezaker   +2 more
doaj  

Mortality Salience and Metabolism: Glucose Drinks Reduce Worldview Defense Caused by Mortality Salience

Psychology, 2012
The current work tested the hypothesis that a glucose drink would reduce worldview defense following mortality salience. Participants consumed either a glucose drink or placebo, wrote about either death or dental pain, and then completed a measure of worldview defense (viewing positively someone with pro-US views and viewing negatively someone with ...
openaire   +3 more sources