Results 141 to 150 of about 1,111,194 (270)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Study of $B_s\to K^{(*)}{\ell }^{+}{\ell }^{-}$ decays in the PQCD factorization approach with lattice QCD input

Physical Review, 2020
In this paper, we studied systematically the semileptonic decays B¯s→K(*)ℓ+ℓ− with l−=(e−,μ−,τ−) by using the perturbative QCD (PQCD) and the “PQCD+Lattice” factorization approach, respectively. We first evaluated all relevant form factors Fi(q2) in the low-q2 region using the PQCD approach, and we also took the available lattice QCD results at the end
Jin, Su-Ping, Hu, Xue-Qing, Xiao, Zhen-Jun   +2 more
openaire  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Optical coherence tomography for surgical demarcation of GI tumor margins for accelerated decision-making during the surgical resection of tumors

Journal of Innovative Optical Health Sciences
Gastric cancer, including stomach tumors, poses significant health challenges due to late-stage diagnosis and limited early detection methods. Accurate imaging and precise tumor margin demarcation are critical for effective treatment planning and ...
Mohamed Nijas Veluthedath, Anuradha Sekaran, Manjoosha R Yerrapragada, Pradeep Rebala, Duvvuru Nageshwar Reddy, Renu John   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Study of density of interface states in MOS structure with ultrathin NAOS oxide

Open Physics, 2012
Jurečka Stanislav, Kobayashi Hikaru, Kim Woo-Byoung, Takahashi Masao, Pinčík Emil   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Fabrication of Al2O3/Al structure by nitric acid oxidation at room temperature

Open Physics, 2010
Iwata Takashi, Matsumoto Taketoshi, Terakawa Sumio, Kobayashi Hikaru   +3 more
doaj   +1 more source