Indian Journal of Paediatric Dermatology, 2023 Ratnakar Shukla, Chirag Desai
openaire +2 more sources
Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Advanced Science, EarlyView.Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Molecular evidence for the association of a strain of Uganda variant of East African cassava mosaic virus to symptom severity in cassava (Manihot esculenta Crantz) fields in Togo [PDF]
, 2009 : Problem statement: This study was carried out to demonstrate that the severity of Cassava Mosaic Disease (CMD) in Togo, is not only influenced by synergism between cassava Begomoviruses in presence, but essentially by recombination between the ...
Adjata, K.D. +4 more
core
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Characterisation and detection of dasheen mosaic potyvirus in Zantedeschia : a thesis presented in partial fulfilment of the requirements for the degree of Master of Horticultural Science in Plant Health at Massey University, Palmerston North, New Zealand [PDF]
, 1995 Four potyvirus isolates believed to be dasheen mosaic potyvirus, the most frequently occurring virus to infect members of the Araceae, were obtained from Caladium, Colocasia, Xanthosoma and Zantedeschia in world-wide locations.
Matthews, Christine Grace
core
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Mosaic spin models with topological order
, 2007 We study a class of two-dimensional spin models with the Kitaev-type couplings in mosaic structure lattices to implement topological orders. We show that they are exactly solvable by reducing them to some free Majorana fermion models with gauge ...
C. P. Sun +4 more
core +1 more source
Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions
Advanced Science, EarlyView.This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang +4 more
wiley +1 more source
Smart environment monitoring through micro unmanned aerial vehicles [PDF]
, 2019 In recent years, the improvements of small-scale Unmanned Aerial Vehicles (UAVs) in terms of flight time, automatic control, and remote transmission are promoting the development of a wide range of practical applications.
Pannone, Daniele
core
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source