Results 61 to 70 of about 179,045 (295)

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Two Edessa Mosaics which were restored in 2011

Journal of Mosaic Research, 2013
In this article, the two mosaic pavements of Edessa that are introduced were restored in Şanlıurfa Archaeological Museum in 2011. One of them is an Aftuha and family mosaic (funeral mosaic D), the other is a geometric patterned mosaic.
Mehmet Önal, Müslüm Ercan, Alain Desreumaux, Nedim Dervişoğlu   +3 more
doaj  

Coding Mutations in Vacuolar Protein-Sorting 4 AAA+ ATPase Endosomal Sorting Complexes Required for Transport Protein Homologs Underlie bc-2 and New bc-4 Gene Conferring Resistance to Bean Common Mosaic Virus in Common Bean

Frontiers in Plant Science, 2021
Bean common mosaic virus (BCMV) is a major disease in common bean (Phaseolus vulgaris L.). Host plant resistance is the most effective strategy to minimize crop damage against BCMV and the related Bean common mosaic necrosis virus (BCMNV).
Alvaro Soler-Garzón, Phillip E. McClean, Phillip N. Miklas   +2 more
doaj   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

A New Pathotype of Pea seedborne mosaic virus Explained by Properties of the P3-6k1- and Viral Genome-Linked Protein (VPg)-Coding Regions

Molecular Plant-Microbe Interactions, 2002
A fourth pathotype of Pea seedborne mosaic virus, a member of the genus Potyvirus, was identified by analysis of the infection profile on a panel of Pisum sativum lines.
Charlotte Kristiane Hjulsager, Ole Søgaard Lund, I. Elisabeth Johansen   +2 more
doaj   +1 more source

The Next Generation Virgo Cluster Survey - Infrared (NGVS-IR): I. A new Near-UV/Optical/Near-IR Globular Cluster selection tool

, 2013
The NGVS-IR project (Next Generation Virgo Survey - Infrared) is a contiguous near-infrared imaging survey of the Virgo cluster of galaxies. It complements the optical wide-field survey of Virgo (NGVS).
Balogh, Michael L., Blakeslee, John P., Boselli, Alessandro, Bournaud, Frédéric, Carlberg, Raymond G., Chapman, Scott C., Courteau, Stéphane, Cuillandre, Jean-Charles, Côté, Patrick, Duc, Pierre-Alain, Durrell, Patrick, Eigenthaler, Paul, Emsellem, Eric, Ferrarese, Laura, Gavazzi, Giuseppe, Gwyn, Stephen, Hudelot, Patrick, Huertas-Company, Marc, Ilbert, Olivier, Jordán, Andrés, Lançon, Ariane, Licitra, Rossella, Liu, Chengze, Läsker, Ronald, MacArthur, Lauren, McConnachie, Alan, McCracken, Henry Joy, Mei, Simona, Mellier, Yannick, Muñoz, Roberto P., Peng, Chien Y., Peng, Eric W., Puzia, Thomas H., Raichoor, Anand, Taylor, Matthew A., Tonry, John L., Tully, R. Brent, Zhang, Hongxin   +37 more
core   +3 more sources

The globular cluster system of NGC 1316. II - The extraordinary object SH2 [PDF]

, 2012
SH2 has been described as an isolated HII-region, located about 6.5 arcmin south of the nucleus of NGC 1316 (Fornax A), a merger remnant in the the outskirts of the Fornax cluster of galaxies.
A. J. Romanowsky, Arnaboldi, B. Dirsch, B. Kumar, Bedregal, Chabrier, Dirsch, D’Onofrio, Goudfrooij, Goudfrooij, Gómez, Horellou, Kim, Kobulnicky, Kobulnicky, Kuntschner, L. P. Bassino, Lanz, Longhetti, Mackie, Marigo, McNeil-Moylan, Nowak, Richtler, Schuberth, Schweizer, Shaya, Sirianni, Stritzinger, T. Richtler   +29 more
core   +3 more sources

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Mosaic inference on panel data

38 pages, 7 ...
Spector, Asher, Barber, Rina Foygel, Candès, Emmanuel   +2 more
openaire   +2 more sources