Results 121 to 130 of about 88,209 (269)
The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes
JCI Insight, 2023 DNAAF5 is a dynein motor assembly factor associated with the autosomal heterogenic recessive condition of motile cilia, primary ciliary dyskinesia (PCD). The effects of allele heterozygosity on motile cilia function are unknown.
Amjad Horani +18 more
doaj +1 more source
Development, Growth and Differentiation, 2020 Motile cilia propel directed cell movements and sweep fluids across the surface of tissues. Orthologs of Dynein Assembly Factor with WD Repeat Domains 1 (DAW1) support normal ciliary beating by enhancing delivery of dynein complexes to axonemal ...
S. L. Lesko, Labib Rouhana
semanticscholar +1 more source
RPGR Isoforms in Photoreceptor Connecting Cilia and the Transitional Zone of Motile Cilia
Investigative Opthalmology & Visual Science, 2003 The retinitis pigmentosa guanosine triphosphatase (GTPase) regulator (RPGR) is essential for photoreceptor survival. There is as yet no consensus concerning the subcellular localization of RPGR. This study was undertaken as a comprehensive effort to resolve current controversies.RPGR in mice and other mammalian species was examined by ...
Alan F. Wright +8 more
openaire +3 more sources
Advanced Science, EarlyView.Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo +16 more
wiley +1 more source
Ciliogenesis and cerebrospinal fluid flow in the developing Xenopus brain are regulated by foxj1 [PDF]
, 2013 Background: Circulation of cerebrospinal fluid (CSF) through the ventricular system is driven by motile cilia on ependymal cells of the brain. Disturbed ciliary motility induces the formation of hydrocephalus, a pathological accumulation of CSF resulting
Feistel, Kerstin +4 more
core +2 more sources
Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
The Geometry of Ciliary Dynamics [PDF]
, 2009 Cilia are motile biological appendages that are driven to bend by internal shear stresses between tubulin filaments. A continuum model of ciliary material is constructed that incorporates the essential ciliary constraints: (1) one-dimensional inextensibility of filaments, (2) three-dimensional incompressibility, and (3) shear strain only along ...
arxiv +1 more source
Phosphoproteins associated with cyclic nucleotide stimulation of ciliary motility in Paramecium [PDF]
, 1990 Permeabilized, MgATP-reactivated cells of Paramecium (models) respond to cyclic AMP and cyclic GMP by increasing forward swimming speed. In association with the motile response, cyclic AMP and 8-bromo-cyclic GMP (8-Br-cyclic GMP) stimulated protein ...
Bonini, Nancy M., Nelson, David L.
core
A Structural Basis for How Motile Cilia Beat [PDF]
BioScience, 2014 The motile cilium is a mechanical wonder, a cellular nanomachine that produces a high-speed beat based on a cycle of bends that move along an axoneme made of 9+2 microtubules. The molecular motors, dyneins, power the ciliary beat. The dyneins are compacted into inner and outer dynein arms, whose activity is highly regulated to produce microtubule ...
Thomas Heuser +2 more
openaire +2 more sources
Advanced NanoBiomed Research, EarlyView.Microalgae are emerging as sustainable and economical bioresources that can be utilized as bioinks for creating constructs with intriguing functionalities. This review discusses the properties and applications of microalgae, providing a comprehensive review of recent advancements and challenges in 3D‐printed microalgae‐based constructs for various ...
Yiwei Zou +3 more
wiley +1 more source