Results 131 to 140 of about 89,658 (280)

Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2 [PDF]

, 2012
Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo.
A. Kawasumi, B. Dworniczak, B. E. Ehrlich, Collignon, Ermakov, G. Sasaki, Gonzalez-Perrett, H. Hamada, H. Sasaki, H. Shiratori, Hirokawa, I. Y. Kuo, J. A. Belo, J. Nakai, K. Shinohara, Koulen, Marques, Marszalek, McGrath, Nauli, Nonaka, P. Pennekamp, Pazour, Pennekamp, Rankin, REYNOLDS, S. Nonaka, S. Yoshiba, Schweickert, Shinohara, Tabin, Tanaka, Tanaka, Y. Asai   +33 more
core   +1 more source

Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers

medRxiv, 2020
We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression
Ivan T. Lee, Tsuguhisa Nakayama, Chien‐Ting Wu, Y. Goltsev, Sizun Jiang, Phillip A. Gall, Chun-Kang Liao, Liang-Chun Shih, C. M. Schurch, D. Mcilwain, Pauline Chu, Nicole A Borchard, David Zarabanda, Sachi S Dholakia, Angela Yang, Dayoung Kim, Tomoharu Kanie, Chia-Der Lin, M. Tsai, Katie M. Phillips, Raymond Kim, J. Overdevest, Matthew A. Tyler, C. Yan, Chih-Feng Lin, Yi-Tsen Lin, D. Bau, G. Tsay, Z. Patel, Yung-An Tsou, Chih-Jaan Tai, T. Yeh, P. Hwang, Garry P. Nolan, J. Nayak, Peter Jackson   +35 more
semanticscholar   +1 more source

Functional CRISPR‐Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity

Biotechnology Progress, EarlyView.
Abstract Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as embryonic development or tumor metastasis. Steps involved in cell migration include cell polarization, formation of membrane protrusions at the cell front side and adhesion disassembly at the rear side, and a general ...
Antonio Mazzei, Sebastian Martewicz, Ramin Amiri, Meihua Cui, Nicola Elvassore, Camilla Luni   +5 more
wiley   +1 more source

Symmetry Breaking in a Model for Nodal Cilia [PDF]

, 2005
Nodal cilia are very short cilia found in the embryonic node on the ventral surface of early mammalian embryos. They create a right to left fluid flow that is responsible for determining the normal asymmetry of the internal organs of the mammalian body ...
Brokaw, Charles J.
core   +1 more source

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda, Joana N. Bugalhao, Marco Antonio Dias Louro, Andreia Henriques‐Soares, Monica Bettencourt‐Dias   +4 more
wiley   +1 more source

Realizing the physics of motile cilia synchronization with driven colloids

, 2015
Cilia and flagella in biological systems often show large scale cooperative behaviors such as the synchronization of their beats in "metachronal waves".
Bruot, Nicolas, Cicuta, Pietro
core   +1 more source

Ciliogenesis and cerebrospinal fluid flow in the developing Xenopus brain are regulated by foxj1 [PDF]

, 2013
Background: Circulation of cerebrospinal fluid (CSF) through the ventricular system is driven by motile cilia on ependymal cells of the brain. Disturbed ciliary motility induces the formation of hydrocephalus, a pathological accumulation of CSF resulting
Feistel, Kerstin, Hagenlocher, Cathrin, Müller, Christina, Thumberger, Thomas, Walentek, Peter   +4 more
core   +2 more sources

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source