Results 141 to 150 of about 89,658 (280)

Synthesis and biological evaluation of heteroarylnitrile derivatives for motile ciliogenesis

Results in Chemistry
Motile cilia play a critical role in maintaining tissue homeostasis by driving fluid movement and clearing inhaled particles or pathogens. Dysfunction of these organelles underlies a range of ciliopathies, most notably affecting the respiratory system ...
Gwi Bin Lee, Gopalakrishnan Chandrasekaran, Da Bin Jeon, Chan-Young Park, Parvathi Varier Sundareswaran, Byeong Wook Choi, Pyeongkeun Kim, Jihyeon Yoon, Seok-Yong Choi, Jin Hee Ahn   +9 more
doaj   +1 more source

Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Despite the well‐known risks of tobacco use, tobacco exposure remains a major contributor to morbidity and mortality worldwide. Although cigarette use has declined, the popularity of novel tobacco products (NTPs), such as electronic cigarettes (ECs) and heated tobacco products (HTPs), has increased.
Timothy S. Leach, Steven Albertson, Phillip W. Clapp, Vikram Surendran, Trang Simon, Eric C. Donny, Stephen J. Walker, Anthony Atala, Sean V. Murphy   +8 more
wiley   +1 more source

Planar Polarity of Motile Cilia

The FASEB Journal, 2008
The ability of ciliated epithelia to generate directed fluid flow is a critical aspect of diverse developmental and physiological processes, including neuroblast migration and proper respiratory function. To achieve directed flow, each ciliated cell needs to generate 100–200 cilia that are coordinately polarized along a common axis both within and ...
openaire   +1 more source

Discovery of a Vertebrate-Specific Factor that Processes Flagellar Glycolytic Enolase during Motile Ciliogenesis

iScience, 2020
Summary: Motile cilia and flagella require ATP for their formation and function. Although glycolytic enzymes are components of flagellar proteomes, how they translocate to flagella is unknown.
Keishi Narita, Hiroaki Nagatomo, Hiroko Kozuka-Hata, Masaaki Oyama, Sen Takeda   +4 more
doaj   +1 more source

Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish [PDF]

, 2016
Background Cerebrospinal fluid (CSF) contained within the brain ventricles contacts neuroepithelial progenitor cells during brain development. Dynamic properties of CSF movement may limit locally produced factors to specific regions of the developing ...
Aponte Santiago, Nicole Ann, Chang, Jessica T., Fame, Ryann M., Hong, Alex, Sive, Hazel L.   +4 more
core   +2 more sources

Case series: Joubert syndrome and eosinophilic esophagitis

JPGN Reports, EarlyView.
Abstract Joubert syndrome (JS) is a rare genetic disorder characterized by developmental abnormalities, particularly in the brainstem and cerebellar vermis, alongside multisystem manifestations such as kidney and liver anomalies, polydactyly, cleft lip or palate, and tongue defects.
Jonathon Schening, Stephanie Leon‐Paredes, Eric Chiou, Vibha Szafron, Anthony Olive, Sara Anvari   +5 more
wiley   +1 more source

Electron cryotomography of intact motile cilia defines the basal body to axoneme transition

Journal of Cell Biology, 2019
Greenan et al. use electron cryotomography on intact motile cilia to elucidate how basal bodies template the formation of motile axonemes.
G. Greenan, R. Vale, D. Agard
semanticscholar   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Primary Ciliary Dyskinesia: An Update on Clinical Aspects, Genetics, Diagnosis, and Future Treatment Strategies [PDF]

, 2017
Primary ciliary dyskinesia (PCD) is an orphan disease (MIM 244400), autosomal recessive inherited, characterized by motile ciliary dysfunction. The estimated prevalence of PCD is 1:10,000 to 1:20,000 live-born children, but true prevalence could be even ...
Abete, Afzelius, Afzelius, Afzelius, Alanin, Altenburg, Bartoloni, Behan, Bhatt, Bilton, Boaretto, Boe, Boon, Boon, Boon, Bradley, Brenner, Brown, Bush, Bush, Campbell, Carotenuto, Chang, Chang, Chernick, Cohen-Cymberknoh, Cole, Coren, Davis, Daviskas, De Benedetti, Desai, Deuse, Eastham, El-Abiad, Eliasson, Elkins, Ellerman, Fedakar, Ferkol, Ferkol, Fliegauf, Fliegauf, Flume, Fokkens, Fretzayas, Frommer, Fuchs, Gokdemir, Goutaki, Halbert, Hart, Hellinckx, Hill, Horani, Horani, Irving, Jeanson, Kartagener, Kellett, Kennedy, Kennedy, Kennedy, Kim, King, Knowles, Knowles, Knowles, Kobbernagel, Konstan, Kott, Kuehni, Kumar, Lai, Lebl, Leigh, Lucas, Lucas, Lucas, Lucas, Macchiarini, Mackerness, Madsen, Maglione, Maglione, Manna, Marks, Marthin, Marthin, Marthin, Mateos-Corral, McManus, Merveille, Mirra, Mitchison, Montella, Montella, Montella, Montella, Moore, Mossberg, Mullowney, Munro, Nakhleh, Nicolson, Noone, Noone, Oktem, Olbrich, Omran, Onoufriadis, Onoufriadis, O’Callaghan, O’Callaghan, Paff, Paff, Papon, Pasteur, Patella, Phillips, Picot, Pifferi, Potter, Prulière-Escabasse, Raidt, Rogers, Rutland, Sagel, Santamaria, Santamaria, Schwabe, Serisier, Shah, Shapiro, Shoemark, Sommer, Spagnolo, Stenbit, Stillwell, Sturgess, Svobodova, ten Berge, Valerio, Walker, Wallmeier, Werner, Werner, Wirschell, Wong, Yan-Wei, Zimmerman   +150 more
core   +1 more source

Cryo-electron tomography of motile cilia and flagella [PDF]

Cilia, 2015
Cryo-electron tomography has been a valuable tool in the analysis of 3D structures of cilia at molecular and cellular levels. It opened a way to reconstruct 3D conformations of proteins in cilia at 3-nm resolution, revealed networks of a number of component proteins in cilia, and has even allowed the study of component dynamics.
openaire   +4 more sources