Results 61 to 70 of about 89,658 (280)

Evolutionarily ancient association of the FoxJ1 transcription factor with the motile ciliogenic program.

PLoS Genetics, 2012
It is generally believed that the last eukaryotic common ancestor (LECA) was a unicellular organism with motile cilia. In the vertebrates, the winged-helix transcription factor FoxJ1 functions as the master regulator of motile cilia biogenesis.
Shubha Vij, Jochen C Rink, Hao Kee Ho, Deepak Babu, Michael Eitel, Vijayashankaranarayanan Narasimhan, Varnesh Tiku, Jody Westbrook, Bernd Schierwater, Sudipto Roy   +9 more
doaj   +1 more source

Reactivation of ethanol-calcium-isolated cilia from Tetrahymena pyriformis [PDF]

, 1967
Cilia isolated from Tetrahymena after ciliary shedding is induced by the addition of CaCl2 or other salts to cells suspended in an ethanol solution (4, 6, 11) have been studied chemically and enzymatically (4, 6, 11, 12, 13), but until now have never ...
Winicur, Sandra
core   +2 more sources

A Flow Cytometry-Based Approach for the Isolation and Characterization of Neural Stem Cell Primary Cilia

Frontiers in Cellular Neuroscience, 2019
In the adult mammalian brain, the apical surface of the subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary cilia originating from rare intermingled neural stem cells (NSCs).
Sara Monaco, Katja Baur, Andrea Hellwig, Gabriele Hölzl-Wenig, Claudia Mandl, Francesca Ciccolini   +5 more
doaj   +1 more source

Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. [PDF]

PLoS Genetics, 2016
Ciliopathies are genetic disorders arising from dysfunction of microtubule-based cellular appendages called cilia. Different cilia types possess distinct stereotypic microtubule doublet arrangements with non-motile or 'primary' cilia having a 9+0 and ...
Wesley R Lewis, Erik B Malarkey, Douglas Tritschler, Raqual Bower, Raymond C Pasek, Jonathan D Porath, Susan E Birket, Sophie Saunier, Corinne Antignac, Michael R Knowles, Margaret W Leigh, Maimoona A Zariwala, Anil K Challa, Robert A Kesterson, Steven M Rowe, Iain A Drummond, John M Parant, Friedhelm Hildebrandt, Mary E Porter, Bradley K Yoder, Nicolas F Berbari   +20 more
doaj   +1 more source

Islet primary cilia motility controls insulin secretion

Science Advances, 2022
Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that primary cilia in human and mouse pancreatic islets exhibit movement that is required for glucose-dependent insulin secretion.
Jung Hoon Cho, Zipeng A. Li, Lifei Zhu, Brian D. Muegge, Henry F. Roseman, Eun Young Lee, Toby Utterback, Louis G. Woodhams, Philip V. Bayly, Jing W. Hughes   +9 more
openaire   +3 more sources

Motile cilia interactome data

, 2023
This data includes XL/MS and structural models for the Tetrahymena motile cilia interactome.
McCafferty, Caitlyn L., Papoulas, Ophelia, Lee, Chanjae, Bui, Khanh Huy, Taylor, David W., Marcotte, Edward M., Wallingford, John B.   +6 more
openaire   +1 more source

Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans

eLife, 2023
Cilia, either motile or non-motile (a.k.a primary or sensory), are complex evolutionarily conserved eukaryotic structures composed of hundreds of proteins required for their assembly, structure and function that are collectively known as the ciliome ...
Rebeca Brocal-Ruiz, Ainara Esteve-Serrano, Carlos Mora-Martínez, Maria Luisa Franco-Rivadeneira, Peter Swoboda, Juan J Tena, Marçal Vilar, Nuria Flames   +7 more
doaj   +1 more source

Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating [PDF]

Mol Biol Cell, 2021
Hiroko Saito, Fumiko Matsukawa Usami, Toshihiko Fujimori, Toshiya Kimura, Takahiro Ide, Takaki Yamamoto, Tatsuo Shibata, Kenta Onoue, Satoko Okayama, Shigenobu Yonemura, Kazuyo Misaki, Yurina Soba, Yasutaka Kakui, Masamitsu Sato, Mika Toya, Masatoshi Takeichi   +15 more
openalex   +3 more sources

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis [PDF]

, 2013
The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms.
A. Harada, H. Hagiwara, M. Kunii, M. Yuzaki, R. Harada, R. Mizuguchi, S. Matsuda, T. Iwano, T. Sato, Y. Jung, Y. Yoshihara   +10 more
core   +2 more sources

An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue [PDF]

, 2013
BACKGROUND: Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the roles of non-motile or primary cilia
Amber K O’Connor, Bradley K Yoder, Courtney J Haycraft, Erik B Malarkey, Mandy J Croyle, Nicolas F Berbari, O’Connor, Amber K, P Darwin Bell, Peter Hohenstein, Robert A Kesterson   +9 more
core   +2 more sources