Results 61 to 70 of about 88,209 (269)
Airway ciliated cells in adult lung homeostasis and COPD
European Respiratory Review, 2023 Cilia are organelles emanating from the cell surface, consisting of an axoneme of microtubules that extends from a basal body derived from the centrioles. They are either isolated and nonmotile (primary cilia), or grouped and motile (motile cilia). Cilia
Laure M.G. Petit +10 more
doaj +1 more source
Mucociliary Wnt signaling promotes cilia biogenesis and beating
Nature Communications, 2023 Motile cilia are thought of as signaling-inert nanomotors. Here, the authors show that motile cilia transduce a Wnt-protein phosphatase 1 signal that regulates cilia biogenesis and ciliary beating in Xenopus embryos and in human airway epithelia.
Carina Seidl +5 more
doaj +1 more source
Scientific Reports, 2021 Cilia are protrusions of the cell surface and composed of hundreds of proteins many of which are evolutionary and functionally well conserved. In cells assembling motile cilia the expression of numerous ciliary components is under the control of the ...
Anja Beckers +14 more
doaj +1 more source
Nonreciprocal interactions give rise to fast cilium synchronisation in finite systems [PDF]
Proc. Natl. Acad. Sci. USA 120, e2307279120 (2023), 2023 Motile cilia beat in an asymmetric fashion in order to propel the surrounding fluid. When many cilia are located on a surface, their beating can synchronise such that their phases form metachronal waves. Here, we computationally study a model where each cilium is represented as a spherical particle, moving along a tilted trajectory with a position ...
arxiv +1 more source
Purification and Immunostaining of Mouse Ependymal Ciliary Shafts
Bio-Protocol, 2022 Cilia and flagella are microtubule-based hair-like organelles protruding from the surface of most eukaryotic cells, and play essential roles in cell locomotion, left-right asymmetry, embryo development, and tissue homeostasis.
Kai Hao, Xueliang Zhu , Xiumin Yan
doaj +1 more source
A multiscale biophysical model gives quantized metachronal waves in a lattice of cilia [PDF]
, 2021 Motile cilia are slender, hair-like cellular appendages that spontaneously oscillate under the action of internal molecular motors and are typically found in dense arrays. These active filaments coordinate their beating to generate metachronal waves that drive long-range fluid transport and locomotion.
arxiv +1 more source
Frontiers in Cellular Neuroscience, 2019 In the adult mammalian brain, the apical surface of the subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary cilia originating from rare intermingled neural stem cells (NSCs).
Sara Monaco +5 more
doaj +1 more source
Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
core +2 more sources
PLoS Genetics, 2012 It is generally believed that the last eukaryotic common ancestor (LECA) was a unicellular organism with motile cilia. In the vertebrates, the winged-helix transcription factor FoxJ1 functions as the master regulator of motile cilia biogenesis.
Shubha Vij +9 more
doaj +1 more source
Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]
, 2010 Background: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
Ingham, P.W. +3 more
core +3 more sources