Results 41 to 50 of about 161,981 (256)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
AgricultureThe small rhizome Chinese herbal medicine harvesting machine is used for excavating the underground rhizomes of Chinese medicinal plants. The reliability of an existing machine of this type was found to be suboptimal due to high vibration levels, as ...
Lixun Dai +5 more
doaj +1 more source
Nonlinear dynamics problems: mathematical models of viscoelastic isotropic plates and shells with smoothly variating thickness (asymmetrical cases) [PDF]
Инженерно-строительный журнал, 2010 More complete mathematical models for the dynamic problems of the isotropic plates and shells with smoothly variatind thickness (asymmetrical cases), which help taking into account both geometrical nonlinearity and possible creeping (viscoelacticity) of ...
V.M. Zhgoutov, R.A. Abdikarimov
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
THE TRACKED VEHICLE MOTION MATHEMATICAL MODEL BASED ON GIBBS-APPELL EQUATIONS
Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015 This article is dedicated to the study of the curvilinear motion of tracked vehicles on the plane. Based on the Gibbs-Appell equations the mathematical model of the tracked vehicle on the two-dimensional surface has been formulated as a mechanical system
Andrii V. Rudyi, Denys V. Rudavskyi
doaj
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Motion Planning Algorithm of a Multi-Joint Snake-Like Robot Based on Improved Serpenoid Curve
IEEE Access, 2020 In order to study the winding motion of a multi-joint snake-like robot with multi-degree of redundancy in plane, a motion planning algorithm of a multi-joint snake-like robot based on improved Serpenoid curve equation is proposed in this paper.
Dongfang Li +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source