Results 51 to 60 of about 4,207,968 (311)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Relationship Between the Motivation to Work with Job Satisfaction of Employees in the Secretariat of the Department of Public Works East District Kutai [PDF]

, 2016
Secretariat of Public Works Bureau of East Kutai is the implementation of tasks in thefield of administrative management of administrative, equipment, public administration andgovernance, as well as the implementation of financial administration tasks ...
Supriadi, S. (Supriadi)
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Building Performance and Work Motivation [PDF]

, 2018
Every company has a purpose,  the establishment of a company has a clear purpose. There are several things that suggest about the purpose of establishing a company. The company's first goal is to achieve maximum profit or profit as much as possible.
Hunein, H. (Hamida)
core  

Ugotavljanje povezav med cilji dosezkov, motivacijo in pricakovanji starsev studentov na Kosovu [PDF]

, 2017
This paper sheds light on the link between achievement goals, motivation, and parental expectations in a sample of 600 students attending higher education institutions in Kosovo.
Grajcevci, Albulene, Shala, Arif
core   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Adolescents, menstruation, and physical activity: insights from a global scoping review

BMC Women's Health
Background Adolescent girls tend to be less physically active than boys, a trend that coincides with puberty. Menstruation may act as a barrier to physical activity, which in turn may influence menstrual symptoms.
Jessica Harvey, Max J. Western, Nick P. Townsend, Jessica Francombe-Webb, Simon Sebire, Olivia S. Malkowski, Masha Remskar, Ella Burfitt, Emma Solomon-Moore   +8 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

The More Interest, the Less Effort Cost Perception and Effort Avoidance

Frontiers in Psychology, 2019
The present study aims to investigate what factors determine students’ engagement in mathematics. We examined the predictive relationships between interest, effort cost (i.e., the cost of making the effort), and three forms of academic engagement ...
Juyeon Song, Sung-il Kim, Mimi Bong
doaj   +1 more source

How do you feel during the COVID-19 pandemic? A survey using psychological and linguistic self-report measures, and machine learning to investigate mental health, subjective experience, personality, and behaviour during the COVID-19 pandemic among university students

BMC Psychology, 2021
Background The WHO has raised concerns about the psychological consequences of the current COVID-19 pandemic, negatively affecting health across societies, cultures and age-groups.
Cornelia Herbert, Alia El Bolock, Slim Abdennadher   +2 more
doaj   +1 more source