Results 31 to 40 of about 588,393 (311)

Motives with modulus, III: The categories of motives

Annals of K-Theory, 2022
Minor corrections. To appear in Ann.
Kahn, Bruno, Miyazaki, Hiroyasu, Saito, Shuji, Yamazaki, Takao   +3 more
openaire   +4 more sources

Exploring individual biases in BCI research and users: Does gender matter?

Frontiers in Human Neuroscience
ObjectiveBrain-Computer Interface (BCI) is an interdisciplinary research field characterized by rapid technological advances and collaborative efforts to develop user-friendly, adaptive devices that enable healthy and non-responsive users to communicate ...
Cornelia Herbert, Viviana Ramos Acuna, Raphael R. K. Kneipp, Nina I. Kapfer   +3 more
doaj   +1 more source

Controllability Attribution as a Mediator in the Effect of Mindset on Achievement Goal Adoption Following Failure

Frontiers in Psychology, 2020
The purpose of this study was to examine the effect of a growth mindset on achievement goal adoption in the face of failure. We also sought to investigate the mediating role of controllability attribution in order to understand the underlying process ...
Juyeon Song, Sung-il Kim, Mimi Bong
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Das Zürcher Ressourcen Modell ZRM

Beiträge zur Lehrerinnen- und Lehrerbildung, 2000
Der Artikel stellt das Zürcher Ressourcen Modell ZRM vor. ZRM wurde für die Universität Zürich entwickelt und ist ein systematisch aufgebautes Training, das Lehrkräften Handlungswissen in den Bereichen Selbstkompetenz und Sozialkompetenz vermittelt. Die
Maja Storch
doaj   +1 more source

Identification of characteristics of foot position and angle during swing phase in fallers using principal component analysis

Frontiers in Bioengineering and Biotechnology, 2023
Identifying the characteristics of fallers is important for preventing falls because such events may reduce quality of life. It has been reported that several variables related to foot positions and angles during gait (e.g., sagittal foot angle and ...
Takuma Inai, Yoshiyuki Kobayashi, Chenhui Huang, Koji Fujita, Masahiro Fujimoto, Fumiyuki Nihey, Akiko Yamamoto, Kanako Nakajima, Kentaro Nakahara, Gaku Kutsuzawa, Kenichiro Fukushi, Shoma Kudo   +11 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source