Results 121 to 130 of about 141,166 (265)
The Motive for Status Maintenance and Inequality in Educational Decisions. Which of the Parents Defines the Reference Point? [PDF]
Several theoretical approaches assume that the motive for status maintenance, that is the desire to avoid intergenerational status downward mobility, explains educational decisions and effects of the families’ social status hereon.
Stocké, Volker
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Disentangling the Importance of the Precautionary Saving Mode [PDF]
We assess the importance of the precautionary saving motive by relying on a direct question about precautionary wealth from the 1995 and 1998 waves of the Survey of Consumer Finances.
Annamaria Lusardi, Arthur Kennickell
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The multiple sources of autonomy as a start-up motive [PDF]
Autonomy is a primary motive for a large majority of small business starters. However, as an explanation of why people want their own (autonomous) business it is largely circular.
Paul Jansen +2 more
core
Stay healthy, be active and work! - Motive analysis of policy proposals on old age [PDF]
, 2011 This article discusses the motives of ageing policies, based on two cases of national policy documents, from Sweden and Poland. The discourse analysis applied in this study follows the key principles of motive analysis.
Wilinska, Monika, Cedersund, Elisabet
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Неофилология, 2017 The notion “mystery” is one of the basic and favourite for F.M. Dostoyevsky. We can say, that F.M. Dostoyevsky himself as “biographic author” with all his creative work and as a human is still not studied, not understood, he is some kind of “great ...
Lyudmila Evgenevna Khvorova +1 more
doaj
Abbreviations for Each Motive and the Full Text for Each Motive.
, 2017 Abbreviations for Each Motive and the Full Text for Each Motive.
Ravi Iyer (140461) +4 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source