Results 41 to 50 of about 9,598,950 (291)

Diagnostic Value of Multimodal Intraoperative Neuromonitoring by Combining Somatosensory-With Motor-Evoked Potential in Posterior Decompression Surgery for Thoracic Spinal Stenosis

Frontiers in Neuroscience, 2022
BackgroundIntraoperative neuromonitoring (IONM) has become an increasingly essential technique in spinal surgery. However, data on the diagnostic value of IONM in predicting impending postoperative neurological deficits (PONDs) for patients who underwent
Tun Liu, Liang Yan, Huaguang Qi, Zhenguo Luo, Xuemei Liu, Tao Yuan, Buhuai Dong, Yuanting Zhao, Songchuan Zhao, Houkun Li, Zhian Liu, Xucai Wu, Fei Wang, Wentao Wang, Yunfei Huang, Gang Wang   +15 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The warning-sign hierarchy between quantitative subcortical motor mapping and continuous motor evoked potential monitoring during resection of supratentorial brain tumors

, 2013
Mapping and monitoring are believed to provide an early warning sign to determine when to stop tumor removal to avoid mechanical damage to the corticospinal tract (CST).
Beck, Jürgen, Seidel, Kathleen, Schucht, Philippe, Raabe, Andreas, Stieglitz, Lennart   +4 more
core   +1 more source

Detection of C8/T1 radiculopathy by measuring the root motor conduction time

BMC Neurology, 2022
Background Root motor conduction time (RMCT) can noninvasively evaluate the status of the proximal root segment. However, its clinical application remains limited, and wider studies regarding its use are scarce.
Dougho Park, Sang-Eok Lee, Jae Man Cho, Joong Won Yang, Donghoon Yang, Mansu Kim, Heum Dai Kwon   +6 more
doaj   +1 more source

Fast acquisition of resting motor threshold with a stimulus–response curve – Possibility or hazard for transcranial magnetic stimulation applications?

Clinical Neurophysiology Practice, 2022
Objective: Previous research has suggested that transcranial magnetic stimulation (TMS) related cortical excitability measures could be estimated quickly using stimulus–response curves with short interstimulus intervals (ISIs).
Elisa Kallioniemi, Friedemann Awiszus, Minna Pitkänen, Petro Julkunen   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Assessing the correlation between sensorimotor evoked potential and cognitive impairment in post-stroke patients

Annals of Human Biology
Background Stroke is a leading cause of death and disability worldwide, with 35–80% of survivors developing cognitive impairment that affects quality of life.
Zhipeng Yan, Hao Luo, Bilian Guo
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Clinical and neurophysiologival efficacy of transcranial magnetic stimulation treatment in patients with stage II Parkinson's disease

Актуальні проблеми сучасної медицини, 2022
Summary. The aim of our study was to determine the clinical and neurophisiological effectiveness of transcranial magnetic stimulation treatment in patients with stage II Parkinson's disease (PD). Materials and methods.
Alina Demchenko, Djamilia Aravitska
doaj   +1 more source