Results 111 to 120 of about 589,719 (314)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Motor Activity-Induced White Matter Repair in White Matter Stroke. [PDF]

J Neurosci, 2023
Marin MA, Gleichman AJ, Wei X, Whittaker DS, Mody I, Colwell CS, Carmichael ST.   +6 more
europepmc   +1 more source

Drug-motivated behavior: The effect of morning glory seeds on motor activity of chicks [PDF]

, 1969
Douglas W. Matheson, Julie Thomas
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

The simple task of lifting five kilograms serves as a predictor of age-related disorders in old adults

Scientific Reports
Muscle weakness is a risk factor for multiple diseases. However, most protocols to assess muscle weakness require clinical settings. A difficulty lifting 5 kg may be a simple measure of muscle weakness in domestic settings.
Rizwan Qaisar, M. Azhar Hussain, Fabio Franzese, Asima Karim, Firdos Ahmad, Atif Awad, Mohammed Alsaeed, Shaea Ayed Alkahtani   +7 more
doaj   +1 more source

KTK MOTOR TEST: REVIEW OF THE MAIN INFLUENCING VARIABLES

Revista Paulista de Pediatria
Objective: To analyze the scientific literature regarding the effects of external variables on KTK motor test scores and to verify which motor tests are associated with KTK.
Whendel Mesquita do Nascimento, Nayana Ribeiro Henrique, Marcelo da Silva Marques   +2 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Quality of life and functional fitness of the elderly

Biomedical Human Kinetics, 2011
Leś Anna, Gaworska Marta
doaj   +1 more source

Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo. [PDF]

Nat Commun, 2023
Karkali K, Vernon SW, Baines RA, Panayotou G, Martín-Blanco E.   +4 more
europepmc   +1 more source

PERSISTENT TIDAL CYCLES OF SPONTANEOUS MOTOR ACTIVITY IN THE FIDDLER CRAB, UCA PUGNAX

, 1957
Miriam F. Bennett, Joan Shriner, Robert A. Brown   +2 more
openalex   +2 more sources