Results 121 to 130 of about 705,013 (318)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Imaging fictive locomotor patterns in larval Drosophila [PDF]

, 2015
S.R.P. was supported by a Newton International Fellowship (Royal Society) and a Junior Fellowship (Janelia Research Campus, Howard Hughes Medical Institute). T.G.B. was supported by a Medical Research Council (UK) PhD grant. J.B. was supported by a Henry
Pulver, Stefan, Taylor, Adam, Bayley, Timothy, Michael Bate (70275), Bate, Michael, Berthold Hedwig (359009), Hedwig, Berthold, Stefan R Pulver (16281800), Berni, Jimena, Jimena Berni (7875149), Timothy G Bayley (16281803), Adam L Taylor (16281806)   +11 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The role of the pre-supplementary motor area in the control of action [PDF]

, 2007
Although regions within the medial frontal cortex are known to be active during voluntary movements their precise role remains unclear. Here we combine functional imaging localisation with psychophysics to demonstrate a strikingly selective ...
O'neill, K, Nachev, P, O'Neill, K., Kennard, C., O’Neill, Kevin, Masud Husain, Nachev, P., Husain, M, Christopher Kennard, Wydell, H, Kennard, Christopher, Husain, M., Wydell, H., Wydell, Henrietta, Parashkev Nachev, Kennard, C, Nachev, Parashkev, Henrietta Wydell, Kevin O’Neill, Husain, Masud   +19 more
core   +1 more source

The relationship between off-ice testing and on-ice performance in male youth Ice hockey players

Frontiers in Sports and Active Living
IntroductionIce hockey demands a unique blend of physical fitness and skill, necessitating a comprehensive understanding of the factors influencing on-ice performance.
Mark S. Rice, Mark S. Rice, Darren E. R. Warburton, Darren E. R. Warburton, Alejandro Gaytan-Gonzalez, Alejandro Gaytan-Gonzalez, Veronica K. Jamnik, Kai Kaufman, Kai Kaufman, Declan R. D. Warburton, Michael Souster, Shannon S. D. Bredin, Shannon S. D. Bredin   +12 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Cell type specific connections from primary motor to primary somatosensory cortex. [PDF]

, 2013
Anatomical studies have shown that primary somatosensory (S1) and primary motor (M1) cortices are reciprocally connected. The pathway from primary motor cortex (M1) to primary somatosensory cortex (S1) is thought to influence activity in S1 by ...
Kinnischtzke, Amanda K
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Sport e Sviluppo Sociale: Modelli a Confronto

Formazione & Insegnamento
Questo studio si addentra nell’esplorazione dello sviluppo sociale attraverso lo sport analizzando tre modelli distinti provenienti da Italia, Finlandia e Brasile.
Matteo Giuriato
doaj