Results 141 to 150 of about 11,248,254 (342)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The effects of osmotic pressure changes on the spontaneous activity at motor nerve endings

, 1956
E. J. Furshpan
openalex   +2 more sources

Drug-motivated behavior: The effect of morning glory seeds on motor activity of chicks [PDF]

, 1969
Douglas W. Matheson, Julie Thomas
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

PERSISTENT TIDAL CYCLES OF SPONTANEOUS MOTOR ACTIVITY IN THE FIDDLER CRAB, UCA PUGNAX

, 1957
Miriam F. Bennett, Joan Shriner, Robert A. Brown   +2 more
openalex   +2 more sources

Patterns of physiological activity accompanying performance on a perceptual motor task. [PDF]

, 1969
Richard I. Thackray
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Nível de atividade física e sua relação com quedas acidentais e fatores psicossociais em idosos de centro de convivência

Revista Brasileira de Geriatria e Gerontologia
Este estudo seccional teve por objetivo estimar o nível de atividade física (NAF) de idosos que frequentam centros de convivência (CCI), analisando a possível associação com quedas acidentais e outras variáveis relacionadas.
Priscila Carneiro Valim-Rogatto, Cecilia Candolo, Ana Cristina Passarella Brêtas   +2 more
doaj   +1 more source

Myokymia and impaired muscular relaxation with continuous motor unit activity. [PDF]

, 1979
Fred Lublin, Peter Tsairis, Leopold J. Streletz, R. Andrew Chambers, Walter F. Riker, Alan Van Poznak, Stéphane Duckett   +6 more
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source