Results 151 to 160 of about 12,676,118 (406)
Arquivos Brasileiros de Cardiologia, 2008 FUNDAMENTO: A prevalência de obesidade e pressão arterial (PA) tem aumentado em crianças e adolescentes, enquanto os domínios da atividade física declinaram. OBJETIVO: Identificar e associar o excesso de peso, de gordura corporal e de PA elevada entre os
Kelly S. Silva, Adair S. Lopes
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Sport e Sviluppo Sociale: Modelli a Confronto
Formazione & InsegnamentoQuesto studio si addentra nell’esplorazione dello sviluppo sociale attraverso lo sport analizzando tre modelli distinti provenienti da Italia, Finlandia e Brasile.
Matteo Giuriato
doaj
Load-velocity relationship in the free-weight horizontal and incline bench press
Scientific ReportsThis study compared (i) the load-velocity relationship in the free-weight horizontal (HBP) vs. incline bench press (IBP) and (ii) the differences between general vs.
Diogo Luís Marques +7 more
doaj +1 more source
Unraveling the fluctuations of animal motor activity
, 2009 Human motor activities are known to exhibit scale-free long-term correlated fluctuations over a wide range of timescales, from few to thousands of seconds. The fundamental processes originating such fractal-like behavior are not yet understood.
Anteneodo, C., Chialvo, D. R.
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source