Results 171 to 180 of about 1,763,344 (306)

OpenStride: an inexpensive, open-source force plate actometry system for quantification of rodent motor activity and behaviour. [PDF]

Sci Rep
Yang Y, Cooper B, Houghton M, Dahiya K, Haslam SE, Blackwell H, Sekaran K, Hu L, Kavehei O, Anderson CJ.   +9 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Special Attention to Diet and Physical Activity in Children and Adolescents With Obesity During the Coronavirus Disease-2019 Pandemic

Frontiers in Pediatrics, 2020
Valeria Calcaterra, Valeria Calcaterra, Matteo Vandoni, Vittoria Carnevale Pellino, Vittoria Carnevale Pellino, Hellas Cena, Hellas Cena   +6 more
doaj   +1 more source

Comparative Study of the Effects of Carvacrol and <i>p</i>-Cymene on the Motor Activity of Rats and Movement of <i>Caenorhabditis elegans</i>. [PDF]

Molecules
Stošić O, Medić D, Marjanović DS, Marić T, Savić V, Nedeljković Trailović J, Zdravković N, Trailović SM.   +7 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

High-definition tDCS of the motor cortex affects prefrontal and primary motor activity differently in young and older adults. [PDF]

Geroscience
Arif Y, Huang PJ, Springer SD, Okelberry HJ, John JA, Petro NM, Garrison GM, Kress KA, McDonald KM, Picci G, Wilson TW.   +10 more
europepmc   +1 more source

Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish. [PDF]

Toxics, 2023
Kim Y, Kim SS, Park BH, Hwang KS, Bae MA, Cho SH, Kim S, Park HC.   +7 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Use of Accelerometers to Monitor Motor Activity During HABIT-ILE for Chronic Stroke: An Exploratory Study. [PDF]

Sensors (Basel)
Somville M, Rosselli Z, Ducoffre E, Penta M, Smeesters T, Bleyenheuft Y, Saussez G.   +6 more
europepmc   +1 more source