Results 191 to 200 of about 7,308,492 (309)

High-definition tDCS of the motor cortex affects prefrontal and primary motor activity differently in young and older adults. [PDF]

Geroscience
Arif Y, Huang PJ, Springer SD, Okelberry HJ, John JA, Petro NM, Garrison GM, Kress KA, McDonald KM, Picci G, Wilson TW.   +10 more
europepmc   +1 more source

Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish. [PDF]

Toxics, 2023
Kim Y, Kim SS, Park BH, Hwang KS, Bae MA, Cho SH, Kim S, Park HC.   +7 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Early Changes in Respiration and Motor Activity After Spinal Cord Injury Predict Pain-Related Outcomes in Mice. [PDF]

Neurotrauma Rep
Chuang A, Hochman S, Noble DJ.
europepmc   +1 more source

Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis. [PDF]

Int J MS Care, 2023
Scherder RJ, van Dorp MJ, Prins AJ, van Klaveren C, Cornelisz I, Killestein J, Weinstein HC.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Impact of Passive Smoking on Vital Signs, Motor Activity, and Agitation in Children Undergoing Dental Extractions Under Sedation: A Short-Term Cohort Study. [PDF]

Healthcare (Basel)
Kaplan EB, Avşar A.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Methods for Wearable-Derived Pulse Rate Measures and Their Application to Modeling the Relationship between Pulse Rate and Motor Activity in Narcolepsy Type 1. [PDF]

Digit Biomark
Kosik-Rose E, Torres R, Tracey B, Olsson T, Volfson D, Onorati F, Karas M.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source