Results 191 to 200 of about 705,013 (318)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Special Attention to Diet and Physical Activity in Children and Adolescents With Obesity During the Coronavirus Disease-2019 Pandemic

Frontiers in Pediatrics, 2020
Valeria Calcaterra, Valeria Calcaterra, Matteo Vandoni, Vittoria Carnevale Pellino, Vittoria Carnevale Pellino, Hellas Cena, Hellas Cena   +6 more
doaj   +1 more source

High-definition tDCS of the motor cortex affects prefrontal and primary motor activity differently in young and older adults. [PDF]

Geroscience
Arif Y, Huang PJ, Springer SD, Okelberry HJ, John JA, Petro NM, Garrison GM, Kress KA, McDonald KM, Picci G, Wilson TW.   +10 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Use of Accelerometers to Monitor Motor Activity During HABIT-ILE for Chronic Stroke: An Exploratory Study. [PDF]

Sensors (Basel)
Somville M, Rosselli Z, Ducoffre E, Penta M, Smeesters T, Bleyenheuft Y, Saussez G.   +6 more
europepmc   +1 more source

Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish. [PDF]

Toxics, 2023
Kim Y, Kim SS, Park BH, Hwang KS, Bae MA, Cho SH, Kim S, Park HC.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Impact of Passive Smoking on Vital Signs, Motor Activity, and Agitation in Children Undergoing Dental Extractions Under Sedation: A Short-Term Cohort Study. [PDF]

Healthcare (Basel)
Kaplan EB, Avşar A.
europepmc   +1 more source

Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis. [PDF]

Int J MS Care, 2023
Scherder RJ, van Dorp MJ, Prins AJ, van Klaveren C, Cornelisz I, Killestein J, Weinstein HC.   +6 more
europepmc   +1 more source