Results 271 to 280 of about 266,743 (342)

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Repetitive Sprinting and Running Fatigue in Children with Different Levels of Motor Competence. [PDF]

Children (Basel)
Coetzee D, du Plessis W, Smits-Engelsman B.   +2 more
europepmc   +1 more source

Examining the relationships among perceived competence, motor skill proficiency, and physical activity behaviour within the framework of physical literacy

, 2018
Jesse Arnett
openalex   +1 more source

Development and preliminary psychometric validation of the Hopscotch Motor Fitness Test (HMFT): a culturally grounded assessment of integrated motor competence in young adults

Tachapon Tongterm, Thamrong Boonprom, Jeeranan Kaewma   +2 more
openalex   +2 more sources

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Biopsychosocial and Environmental Correlates of Children's Motor Competence: An Exploratory Study. [PDF]

Sports Med Open
Algurén B, Tang Y, Pelletier C, Naylor PJ, Faulkner G.   +4 more
europepmc   +1 more source

The effects of sex-linked tasks on perceived competence and motor performance

, 1994
Marie Labriola
openalex   +1 more source

Influence of dietary habits, screen time, and sleep on anthropometric variables, physical fitness, and Motor Competence in Preschool Children

Andrés Godoy-Cumillaf, Paola Fuentes Merino, Josivaldo de Souza-Lima, Catalina Muñoz-Strale, Frano Giakoni-Ramírez, Maribel Parra-Saldías, Daniel Duclos-Bastias, José Bruneau-Chávez, Eugenio Merellano-Navarro   +8 more
openalex   +2 more sources

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Motor competence of children in Singapore using Movement ABC-2 test. [PDF]

PeerJ
Tan JSY, Chia M.
europepmc   +1 more source