Results 171 to 180 of about 2,267,071 (351)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Entrepreneurship, organization and economic performance among Spanish firms, 1930-1975. The case of the motor industry [PDF]
Before the Civil War (1936-1939), Spain had seen the emergence of firms of complex organizational forms. However, the conflict and the postwar years changed this pattern.
Albert Carreras, Salvador Estapé Triay
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The effect of endurance training combined with creatine monohydrate supplementation on the development of selected physical and motor abilities in advanced taekwondo athletes [PDF]
Thaer Fadel Alwan, Ghosoun Fadel Hadi
openalex +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Examining the Impact of Young Children's Motor Development on Inhibitory Control and Social Skills. [PDF]
Children (Basel)Brian A +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The contributions of biological maturity and experience to fine motor development in adolescence. [PDF]
Sci RepBerencsi A +7 more
europepmc +1 more source
The eastern cape automotive cluster: a key sector for regional economic growth and development [PDF]
In terms of the human development index, the Eastern Cape Province is the second poorest of the nine provinces in South Africa. The Province suffers from high levels of unemployment and illiteracy, low levels of international competitiveness and ...
Horn, Gideon
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source