Results 181 to 190 of about 17,961,119 (345)

Motor development and delay: advances in assessment of motor skills in autism spectrum disorders

Current Opinion in Neurology, 2018
Rujuta B. Wilson, P. Enticott, N. Rinehart   +2 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Study on the motor development and biomechanical characteristics of children aged 3-5 years. [PDF]

Front Public Health
Hou B, Zhao J, Ji Z, Jiang G, Song Z.
europepmc   +1 more source

Gross Motor Development in Children Aged 3–5 Years, United States 2012

Maternal and Child Health Journal, 2017
Brian K. Kit, Lara J. Akinbami, N. S. Isfahani, D. Ulrich   +3 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Association Between Exposure to Smartphones and Tablets and Motor Development in Early Childhood: A Systematic Review. [PDF]

Child Care Health Dev
Dutra RP, Castro YM, Moran V, Mattos VGW, Rodrigues PVM, Bacil EDA, da Silva MP.   +6 more
europepmc   +1 more source

Breastfeeding and motor development in term and preterm infants in a longitudinal US cohort.

American Journal of Clinical Nutrition, 2017
K. Michels, A. Ghassabian, S. Mumford, R. Sundaram, E. Bell, Scott C. Bello, E. Yeung   +6 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Influence of Sex, Family Structure, and Access to Technology on the Motor Development of Children Aged 24 to 48 Months. [PDF]

Healthcare (Basel)
Rebelo M, Adrião R, Batista M, Honório S, Mesquita H, Marques C, Serrano J.   +6 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source