FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A High-Performance and Cost-Effective Field Programmable Gate Array-Based Motor Drive Emulator. [PDF]
Micromachines (Basel), 2023 Hernandez J +2 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Sensor Fault Diagnosis Method Based on Rotor Slip Applied to Induction Motor Drive. [PDF]
Sensors (Basel), 2022 Tran CD +4 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Integrated Motor Drive and Non-Isolated Battery Charger Based on the Torque Cancelation in the Motor
, 2013 For a plug-in vehicle, the traction circuit components like electric motor, inverter, and sensors are not used during the battery charging. So there is a possibility to use them in the battery charger circuit that is called an integrated motor drive and ...
Serrano, Isabel, +5 more
core +1 more source
Rapid virtual prototyping of electric vehicles using DQ behavioral model of a brushless DC motor
This paper presents a system level for the effective and rapid design and evaluation of a complete electric vehicle system. Several critical components are examined including the mechanical model of the vehicle, the electric motor (with its associated ...
Brown, Andrew D. +2 more
core +1 more source
Prior Involvement of Central Motor Drive Does Not Impact Performance and Neuromuscular Fatigue in a Subsequent Endurance Task. [PDF]
Med Sci Sports Exerc, 2022 Laginestra FG +9 more
europepmc +1 more source