Results 161 to 170 of about 884,436 (268)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Performance-driven switched reluctance motor drive using multiport cascaded converter and advanced direct torque control scheme. [PDF]

Sci Rep
Deepak M, Santhakumar K, Sathiyasekar K, Chokkalingam B, Padmanaban S.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Sensor fault diagnosis strategy based on rotor flux observers in three-phase induction motor drive. [PDF]

Sci Rep
Tran CD, Kuchar M, Sotola V, Nguyen PD.
europepmc   +1 more source

Common drive unit [PDF]

The Common Drive Unit (CDU) is a high reliability rotary actuator with many versatile applications in mechanism designs. The CDU incorporates a set of redundant motor-brake assemblies driving a single output shaft through differential.
Ellis, R. C., Fink, R. A., Moore, E. A.
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Improved speed control of dual induction motor drive powered by a single five-leg VSI. [PDF]

Sci Rep
Kondratenko D, Lewicki A, Łuksza K.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Sensorless Direct Field-Oriented Control of Induction Motor Drive Using Artificial Neural Network-Based Reactive Power MRAS. [PDF]

Sensors (Basel)
Kubatko M, Bielesz D, Kirschner S, Hamani K, Kuchar M, Mrovec T, Prazenica M.   +6 more
europepmc   +1 more source

Virtual Current Sensor in the Fault-Tolerant Field-Oriented Control Structure of an Induction Motor Drive. [PDF]

Sensors (Basel), 2019
Adamczyk M, Orlowska-Kowalska T.
europepmc   +1 more source