Results 61 to 70 of about 10,064,866 (298)
Актуальні проблеми сучасної медицини, 2022 Summary. The aim of our study was to determine the clinical and neurophisiological effectiveness of transcranial magnetic stimulation treatment in patients with stage II Parkinson's disease (PD). Materials and methods.
Alina Demchenko, Djamilia Aravitska
doaj +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Repeatability of corticospinal and spinal measures during lengthening and shortening contractions in the human tibialis anterior muscle [PDF]
, 2012 Elements of the human central nervous system (CNS) constantly oscillate. In addition, there are also methodological factors and changes in muscle mechanics during dynamic muscle contractions that threaten the stability and consistency of transcranial ...
Hortobágyi, Tibor +20 more
core +1 more source
Frontiers in Neurology, 2022 ObjectiveTranscranial ultrasound stimulation (TUS) is a new form of non-invasive brain stimulation. Low-intensity TUS is considered highly safe. We aimed to investigate the effect of low-intensity TUS on hand reaction responses and cortical excitability ...
Meng-Fei Zhang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Illustrative motor evoked potential.
, 2019 Single-subject data showing an averaged trace of electromyographic (EMG) activity in the first dorsal interosseous (FDI) muscle during relaxation. The arrow shows the timing of single-pulse transcranial magnetic stimulation (TMS) delivered over the ...
Alex Dilena (7252058) +4 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Mapping the cortical representation of the lumbar paravertebral muscles [PDF]
, 2007 Objective: The aim of this study was to map the cortical representation of the lumbar spine paravertebral (LP) muscles in healthy subjects. Methods: Transcranial magnetic stimulation (TMS) was employed to map the cortical representations of the LP ...
Cossar, J +3 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2010 Objective: To delineate whether functional recovery after stroke, determined by the modified Rankin Scale during the neurologically stable chronic stage, is associated with the presence or absence of motor evoked potential or somatosensory evoked ...
NJ Paik +11 more
core +1 more source