Results 91 to 100 of about 1,642,125 (295)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Motor-evoked responses in primary lateral sclerosis.

open access: yes, 1992
Primary lateral sclerosis (PLS) may be distinguished on the basis of clinical and pathological features from amyotrophic lateral sclerosis (ALS). The former is featured by a much longer clinical course, exclusively upper motor neuron findings, losses of ...
A. J. Hudson   +4 more
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

open access: yesFEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa   +4 more
wiley   +1 more source

Examples of motor and somatosensory evoked potentials.

open access: yes, 2021
A) Example of a motor evoked potential (MEP); B) Example of a Somatosensory Evoked Potential (SSEP). (TIF)
Pablo Brea Winckler (11773044)   +8 more
core   +1 more source

Ketamine-Based Anesthetic Protocols and Evoked Potential Monitoring: A Risk/Benefit Overview

open access: yesFrontiers in Neuroscience, 2016
Since its discovery, ketamine, a noncompetitive N-methyl D-aspartate (NMDA) receptor antagonist related to phencyclidine, has been linked to multiple adverse reactions sometimes described as out of body and near death experiences, including emergence ...
Nicoleta eStoicea   +8 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

Scatter plots showing latencies of motor evoked potentials and somatosensory evoked potentials of NMO patients.

open access: yes, 2014
A. CxL in upper limbs; B, upper limb motor CCT; C, CxL in lower limbs; D, lower limb motor CCT; E, N20; F, upper limb sensory CCT; G, P40; H, lower limb sensory CCT. Black dots indicate patients with a relapse.
Ming-Fen Lao (665756)   +10 more
core   +1 more source

SOMATOSENSORY AND MOTOR EVOKED POTENTIALS AS PROGNOSTIC INDICATOR OF WALKING AFTER SPINAL CORD INJURY

open access: yesInternational Journal of Physiotherapy, 2015
Background: Walking recovery is one of the main goals of patients after SCI. Walking is rated as primary goal and desire (together with bladder and bowel function) irrespective of the level of lesion. Past literature terms walking as long-term outcome or
Parneet Kaur Bedi , Narkeesh Arumugam
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

Prognostic Values of Motor Evoked Potentials in Insular, Precental, or Postcentral Resections

open access: yes, 2016
To determine the predictive values of motor evoked potentials (MEPs) on the muscle strength of patients undergoing insular and/or around precentral or postcentral ...
Boex, Colette   +7 more
core   +1 more source

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