Results 81 to 90 of about 1,642,125 (295)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Somatosensory evoked potentials in lacunar syndromes of pure motor and ataxic hemiparesis.

, 1987
Syndromes of hemiparetic lacunar infarction include pure motor hemiparesis and ataxic hemiparesis. Twelve such patients were evaluated with somatosensory evoked potentials.
S J Perlik, M A Kelly, M A Fisher
core   +1 more source

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Ten Bruggencate, Gerrit, Galvan, Martin, Grafe, Peter   +2 more
core   +1 more source

Transcranial static magnetic field stimulation - new non-invasive brain stimulation tool

Journal of Physical Fitness and Sports Medicine, 2016
Recent research has shown that the human motor cortex can be modulated by the application of static magnetic fields through the scalp. Transcranial static magnetic field stimulation (tSMS) has since received significant attention as a new non-invasive ...
Hikari Kirimoto, Hiroyuki Tamaki, Hideaki Onishi   +2 more
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Efficacy of transcranial motor-evoked myogenic potentials to detect spinal cord ischemia during operations for thoracoabdominal aneurysms [PDF]

, 1997
Objective: Motor-evoked myogenic potentials after transcranial electrical stimulation monitor the vulnerable motoneuronal system of the spinal cord. This study reports our initial experiences with motor-evoked potentials to assess the adequacy of spinal ...
Veldman, Dirk J., de Haan, P., Jacobs, M.J.H.M., Kalkman, Cor J., de Mol, B.A.J.M., de Mol, B. A., Veldman, D. J., de Mol, Bas A., Jacobs, M. J., Ubags, L.H.H.M., Ubags, L. H., Kalkman, C. J., de Haan, Peter, Ubags, Leon H., Kalkman, C.J., Veldman, D.J., Jacobs, Michael J.H.M.   +16 more
core   +2 more sources

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Statistical Model of Motor-Evoked Potentials

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2019
Motor-evoked potentials (MEPs) are widely used for biomarkers and dose individualization in transcranial stimulation. The large variability of MEPs requires sophisticated methods of analysis to extract information fast and correctly. Development and testing of such methods relies on the availability for realistic models of MEP generation, which are ...
Stefan M. Goetz, S. M. Mahdi Alavi, Zhi-De Deng, Angel V. Peterchev   +3 more
openaire   +3 more sources

Predictive Performance of Machine Learning with Evoked Potentials for SCI and MS Prognosis: A Meta-Analysis

Clinical and Translational Neuroscience
Evoked potentials (EPs), including somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs), are used to assess neural conduction in spinal cord injury (SCI) and multiple sclerosis (MS), conditions marked by demyelination, inflammation,
Constantinos Koutsojannis, Dionysia Chrysanthakopoulou   +1 more
doaj   +1 more source