Results 191 to 200 of about 720,495 (268)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Effects of dual-task training on gross motor function, balance, and gait in children with cerebral palsy: a systematic review and meta-analysis. [PDF]

Front Neurol
Peng B, Sun Q.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Study on the effectiveness and safety of balance instrument training on balance and lower limb motor function in patients with ischemic stroke hemiplegia. [PDF]

Front Rehabil Sci
Chen Z, Chen H, Wang J, Lu H.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice. [PDF]

J Clin Invest
Torres M, Lu Y, Pederson B, Wang H, Gretzinger A, Lin LL, Hwang J, Chen X, Rupp AC, Tomlinson AJ, Scott AJ, Zhao Z, Wahl DR, Myers MG, Lyssiotis CA, Qi L.   +15 more
europepmc   +1 more source

Leveraging neural drive to assess hand motor function in individuals with chronic stroke. [PDF]

J Neuroeng Rehabil
Tacca N, Levine JT, Heimann MK, Schlink BR, Cady S, Colachis SC, Baumgart I, Bollinger A, Dunlap C, Putnam P, Darrow MJ, Wengerd L, Pons JL, Friedenberg DA, Meyers EC.   +14 more
europepmc   +1 more source

Roles of the Cholinergic and Adrenergic Systems in Vagus Nerve Stimulation for the Recovery of Motor Function in Patients with Stroke: Opportunities for Novel Treatments and Rehabilitation. [PDF]

Int J Mol Sci
Abdullahi A, Wong TWL, Ng SSM.
europepmc   +1 more source

The effectiveness of transcranial magnetic stimulation in ameliorating limb motor function disorders after stroke: an umbrella review. [PDF]

Front Neurol
Yao X, Luo M, Zhang W, Shen Y, Feng L, Liang C, Wang D, Cheng X, Tang J.   +8 more
europepmc   +1 more source