Results 231 to 240 of about 6,790,416 (306)

A Quantitative Assessment of Upper Limb Motor Function Across Disease Stages in Hereditary Transthyretin Amyloidosis. [PDF]

J Peripher Nerv Syst
Hamedani M, Prada V, Massucco S, Roveta E, Grandis M, Gemelli C, Schiavetti I, Signori A, Schenone C, Luigetti M, Guglielmino V, Sciarrone MA, Vitali F, Pradotto LG, Manganelli F, Tozza S, Palumbo G, Mazzeo A, Gentile L, Russo M, Luca M, D'Arma F, Pisciotta C, Fenu S, Pareyson D, Schenone A.   +25 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Barriers and levers to using an app for motor function assessment by therapists in hospitals: A qualitative study of the MFM-Play app. [PDF]

PLoS One
Vincent-Genod D, Verroul M, Rippert P, Tachibana S, Vuillerot C, MFM-Play Study Group.   +5 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Recovery of Hindlimb Motor Function Is Accompanied by Lumbar Neural Remodeling After Complete Spinal Cord Transection in Neonatal Mice. [PDF]

Biology (Basel)
Peng W, Li R, Zhang L, Long W, Yang Y, Wang M, Song L, Li J.   +7 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Clinical efficacy of neuromodulation in isolated dystonia: A systematic review of motor function improvement. [PDF]

Neurol Sci
Carta D, Lo Buono V, Culicetto L, Bertino S, Terranova C, Formica C, Quartarone A, Marino S.   +7 more
europepmc   +1 more source

Changes in motor function, quality of life, and clinical manifestations in patients with Alpha-mannosidosis treated with Velmanase Alfa: Data from the French Étoile Alpha registry. [PDF]

Mol Genet Metab Rep
Guffon N, Mention-Mulliez K, Gaches F, Garavaglia D, Salomone F, Héron B.   +5 more
europepmc   +1 more source

Screen time, smartphone addiction, and executive-motor function in Tunisian middle school students. [PDF]

Front Psychol
Yaakoubi M, Ghorbel A, Abdelkafi H, Alsaeed MI, Bouchiba M, Masmoudi L, Said NB, Woll A, Scharenberg S, Kammoun MM, Trabelsi O, Gharbi A.   +11 more
europepmc   +1 more source