Results 81 to 90 of about 130,693 (253)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Optimized preoperative motor cortex mapping in brain tumors using advanced processing of transcranial magnetic stimulation data

NeuroImage: Clinical, 2019
Background and objective: Transcranial magnetic stimulation (TMS) is a useful technique to help localize motor function prior to neurosurgical procedures.
Laura Seynaeve, Tom Haeck, Markus Gramer, Frederik Maes, Steven De Vleeschouwer, Wim Van Paesschen   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Visuomotor expertise in volleyball: saccadic latency and absolute alpha power

Frontiers in Psychology
This study investigated differences in saccadic latency and absolute alpha power during eye movement preparation between young volleyball athletes and non-athletes.
Renan Vicente, Renan Vicente, Juliana Bittencourt, Renato Fonseca, Renato Fonseca, Giovanna Zanchetta, Giovanna Zanchetta, Alexandre Vasconcelos, Carlos Amoroso, Carlos Amoroso, Marcos Machado, Marcos Machado, Elida Costa, Isabelle Fernandes, Isabelle Fernandes, Victor Marinho, Jesse Di Giacomo, Jesse Di Giacomo, Eduardo Nicoliche, Danielle Aprigio, Marcelo Nobre, Marcelo Nobre, Marco Orsini, Victor Hugo Bastos, Silmar Teixeira, Antonio E. Nardi, Mauricio Cagy, Bruna Velasques, Bruna Velasques, Pedro Ribeiro, Pedro Ribeiro, Henning Budde   +31 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

NeuroMeasure: A Software Package for Quantification of Cortical Motor Maps Using Frameless Stereotaxic Transcranial Magnetic Stimulation

Frontiers in Neuroinformatics, 2019
The recent enhanced sophistication of non-invasive mapping of the human motor cortex using MRI-guided Transcranial Magnetic Stimulation (TMS) techniques, has not been matched by refinement of methods for generating maps from motor evoked potential (MEP ...
Michael B. Gerber, Alasdair C. McLean, Samuel J. Stephen, Alex G. Chalco, Usman M. Arshad, Gary W. Thickbroom, Josh Silverstein, K. Zoe Tsagaris, Amy Kuceyeski, Kathleen Friel, Kathleen Friel, Taiza E. G. Santos, Dylan J. Edwards, Dylan J. Edwards   +13 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Electrocorticographic Temporal Alteration Mapping: A Clinical Technique for Mapping the Motor Cortex with Movement-Related Cortical Potentials

Frontiers in Neuroscience, 2017
We propose electrocorticographic temporal alteration mapping (ETAM) for motor cortex mapping by utilizing movement-related cortical potentials (MRCPs) within the low-frequency band [0.05-3] Hz.
Zehan Wu, Tao Xie, Lin Yao, Dingguo Zhang, Xinjun Sheng, Dario Farina, Liang Chen, Ying Mao, Xiangyang Zhu   +8 more
doaj   +1 more source