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Brain Tumors [PDF]

open access: yesSeminars in Nuclear Medicine, 2012
This review addresses the specific contributions of nuclear medicine techniques, and especially positron emission tomography (PET), for diagnosis and management of brain tumors. (18)F-Fluorodeoxyglucose PET has particular strengths in predicting prognosis and differentiating cerebral lymphoma from nonmalignant lesions.
Herholz, Karl; id_orcid 0000-0002-8658-0151   +3 more
openaire   +5 more sources

Brain tumors [PDF]

open access: yesCA: A Cancer Journal for Clinicians, 1993
At the same time that studies indicate an increase in the frequency of brain tumors, improvements in diagnosis and treatment have increased the clinician's ability to deal with these cancers. Dr. Posner, Chairman of the Department of Neurology at Memorial Sloan-Kettering Cancer Center in New York City, encourages physicians to be alert for symptoms of ...
E R, Laws, K, Thapar
openaire   +4 more sources

HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis

open access: yesCell Death and Disease, 2022
Patients with glioblastoma (GBM) have poor prognosis and limited treatment options, largely due to therapy resistance upon the induction of apoptosis.
Xiaodong Su   +6 more
doaj   +1 more source

Feasibility of dendritic cell-based vaccine against glioblastoma by using cytoplasmic transduction peptide (CTP)-fused protein antigens combined with anti-PD1

open access: yesHuman Vaccines & Immunotherapeutics, 2020
Recent clinical trials utilizing antigen-pulsed dendritic cells (DCs) have demonstrated increased survival of vaccinated cancer patients. Besides, the cytoplasmic transduction peptide (CTP) not only has an excellent transcellular efficiency but also ...
Young-Hee Kim   +9 more
doaj   +1 more source

Glioma-associated mesenchymal stem cells-mediated PD-L1 expression is attenuated by Ad5-Ki67/IL-15 in GBM treatment

open access: yesStem Cell Research & Therapy, 2022
Background Glioblastoma (GBM) is a highly immunosuppressive and vascular malignant brain tumor. Current therapeutic strategies targeting tumor cells have limited efficacy because of the immunosuppressive microenvironment and vascularization.
Qing Zhang   +5 more
doaj   +1 more source

A conjoined universal helper epitope can unveil antitumor effects of a neoantigen vaccine targeting an MHC class I-restricted neoepitope

open access: yesnpj Vaccines, 2021
Personalized cancer vaccines targeting neoantigens arising from somatic missense mutations are currently being evaluated for the treatment of various cancers due to their potential to elicit a multivalent, tumor-specific immune response.
Adam M. Swartz   +10 more
doaj   +1 more source

Brain Tumor [PDF]

open access: yesThe Journal of Nervous and Mental Disease, 1919
n ...
openaire   +4 more sources

Sarcosine promotes trafficking of dendritic cells and improves efficacy of anti-tumor dendritic cell vaccines via CXC chemokine family signaling

open access: yesJournal for ImmunoTherapy of Cancer, 2019
Background Dendritic cell (DC) vaccine efficacy is directly related to the efficiency of DC migration to the lymph node after delivery to the patient.
Farhad Dastmalchi   +10 more
doaj   +1 more source

MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization

open access: yesScientific Reports, 2022
Glioblastoma (GBM) is a lethal brain cancer known for its potent immunosuppressive effects. Loss of Methylthioadenosine Phosphorylase (MTAP) expression, via gene deletion or epigenetic silencing, is one of the most common alterations in GBM. Here we show
Landon J. Hansen   +7 more
doaj   +1 more source

Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas

open access: yesNature Communications, 2023
Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification of patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring.
Grayson A. Herrgott   +34 more
doaj   +1 more source

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