Results 31 to 40 of about 643,956 (165)
Stem Cells International, 2016 Serum-free culture methods for patient-derived primary glioma cultures, selecting for glioma stem-like cells (GSCs), are becoming the gold standard in neurooncology research.
A. Kleijn +6 more
doaj +1 more source
Frontiers in Neurology, 2020 Objective: To explore the prognostic significance of metabolic parameters in postoperative peritumoral edema zone (PEZ) of patients with glioblastoma (GBM) based on proton magnetic resonance spectroscopy (MRS).Methods: The postoperative MRS data of 67 ...
Yong Cui +14 more
doaj +1 more source
Journal of Experimental & Clinical Cancer ResearchBackground Chimeric antigen receptor (CAR) T-cell therapy has shown limited efficacy in glioblastoma (GBM) due to tumor antigen heterogeneity and the immunosuppressive microenvironment.
Sheng Fang +8 more
doaj +1 more source
Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
Nature Communications, 2023 Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation.
Mark W. Youngblood +36 more
doaj +1 more source
Neurologia medico-chirurgica, 1999 The first section of this article focuses on epidemiology, cause, diagnosis, and treatment of brain tumors in children and adolescents. The second section addresses the long-term consequences of tumors and their treatment, and a special emphasis is paid to cognitive and psychological outcomes.
J, Siffert +3 more
openaire +5 more sources
Scientific ReportsMany cancers evade immunosurveillance by downregulating surface major histocompatibility class (MHC)-I. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes MHC-I degradation and is elevated in glioma.
Kirit Singh +27 more
doaj +1 more source
Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells
Scientific Reports, 2023 Raising reactive oxygen species (ROS) levels in cancer cells to cause macromolecular damage and cell death is a promising anticancer treatment strategy. Observations that electromagnetic fields (EMF) elevate intracellular ROS and cause cancer cell death,
Shashank Hambarde +4 more
doaj +1 more source
Stem Cell Reports, 2016 The challenges to effective drug delivery to brain tumors are twofold: (1) there is a lack of non-invasive methods of local delivery and (2) the blood-brain barrier limits systemic delivery. Intranasal delivery of therapeutics to the brain overcomes both
Mahua Dey +12 more
doaj +1 more source
Identification of tumor rejection antigens and the immunologic landscape of medulloblastoma
Genome MedicineBackground The current standard of care treatments for medulloblastoma are insufficient as these do not take tumor heterogeneity into account. Newer, safer, patient-specific treatment approaches are required to treat high-risk medulloblastoma patients ...
Changlin Yang +6 more
doaj +1 more source
Nature Communications, 2023 Glioblastoma is an immunologically cold tumour, with poor CD8 + T cell infiltration and enrichment in immunosuppressive tumour-associated myeloid cells. Here, the authors generate a bispecific lipid nanoparticle targeting CD47 and PD-L1, combined with a ...
Peng Zhang +18 more
doaj +1 more source