Results 41 to 50 of about 643,956 (165)

Brain Tumors in Children [PDF]

Archives of Neurology, 1995
Brain tumors are the most common form of solid neoplasm of childhood. Progress in the treatment of childhood brain tumors has been frustratingly slow, especially in comparison with other pediatric malignancies. The biology of primary pediatric brain tumors of childhood is just being unraveled.
openaire   +4 more sources

A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1

Scientific Reports, 2022
Forkhead Box M1 (FOXM1) is known to regulate cell proliferation, apoptosis and tumorigenesis. The lignan, (−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol (DFS), from Alnus japonica has shown anti-cancer effects against colon cancer cells by suppressing ...
Jin-Kyoung Shim, Seung Hoon Lim, Ji Hye Jeong, Ran Joo Choi, Yoojung Oh, Junseong Park, Sunghee Choi, Junpyo Hong, Seo Jin Kim, Ju Hyung Moon, Eui Hyun Kim, Wan-Yee Teo, Bong Jin Park, Jong Hee Chang, Jae-Ha Ryu, Seok-Gu Kang   +15 more
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Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles

Pharmaceutics, 2020
Alternative routes of administration are one approach that could be used to bypass the blood−brain barrier (BBB) for effective drug delivery to the central nervous system (CNS). Here, we focused on intranasal delivery of polymer nanoparticles.
Eugene P. Chung, Jennifer D. Cotter, Alesia V. Prakapenka, Rebecca L. Cook, Danielle M. DiPerna, Rachael W. Sirianni   +5 more
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Optimized culturing yields high success rates and preserves molecular heterogeneity, enabling personalized screening for high-grade gliomas

npj Precision Oncology
To discover new treatment options for high-grade glioma (HGG), robust in vitro models are essential, but reliably establishing patient-derived cell cultures remains challenging. We established glioma stem-like cell (GSC) cultures from 114 consecutive HGG
Cassandra Posthoorn-Verheul, Federica Fabro, Ioannis Ntafoulis, Chelsea den Hollander, Iris S. C. Verploegh, Rutger Balvers, Trisha V. Kers, Jessica Hoogeveen, Judith van der Burg, Bert Eussen, Annelies de Klein, Kate J. Feller, Miao-Ping Chien, Clemens M. F. Dirven, Sieger Leenstra, Martine L. M. Lamfers   +15 more
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Expanded specific T cells to hypomutated regions of the SARS-CoV-2 using mRNA electroporated antigen-presenting cells

Molecular Therapy: Methods & Clinical Development
The COVID-19 pandemic has caused about seven million deaths worldwide. Preventative vaccines have been developed including Spike gp mRNA-based vaccines that provide protection to immunocompetent patients. However, patients with primary immunodeficiencies,
Elizabeth Ogando-Rivas, Paul Castillo, Changlin Yang, Vrunda Trivedi, Dingpeng Zhang, Fernanda Pohl-Guimarães, Ruixuan Liu, Arnav Barpujari, Kate M. Candelario, Hector Mendez-Gomez, Elias J. Sayour, Duane A. Mitchell   +11 more
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From Patient-Specific Mathematical Neuro-Oncology to Precision Medicine

Frontiers in Oncology, 2013
Gliomas are notoriously aggressive, malignant brain tumors that have variable response to treatment. These patients often have poor prognosis, informed primarily by histopathology.
Anne eBaldock, Anne eBaldock, Russell eRockne, Russell eRockne, Addie eBoone, Maxwell eNeal, Maxwell eNeal, Carly eBridge, Carly eBridge, Laura eGuyman, Laura eGuyman, Maceij eMrugala, Jason eRockhill, Kristin Rae Swanson, Kristin Rae Swanson, Kristin Rae Swanson, Andrew Daniel Trister, A eHawkins-Daarud, A eHawkins-Daarud, David M Corwin, David M Corwin   +20 more
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HYDATID TUMORS OF THE BRAIN. [PDF]

Journal of the American Medical Association, 1885
Sir: —Allow me to call attention to two points in the paper by Dr. R. Harvey Reed, on "Hydatid Tumor of the Brain," published in theJournalof July 4th. (1) The term hydatid tumor should be, and usually is, limited to the echinococcus cyst, the larvae of the Taenia echinococcus or Hydatid tapeworm.
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The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity

Molecular Therapy: Oncolytics, 2017
The conditionally replicating oncolytic adenovirus Delta24-RGD (Ad) is currently under investigation in clinical trials for glioblastoma, including in combination with temozolomide (TMZ), the standard chemotherapy for this tumor.
Anne Kleijn, Wouter van den Bossche, Erik S. Haefner, Zineb Belcaid, Chantal Burghoorn-Maas, Jenneke J. Kloezeman, Suzan D. Pas, Sieger Leenstra, Reno Debets, Jeroen de Vrij, Clemens M.F. Dirven, Martine L.M. Lamfers   +11 more
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Manipulation of Innate and Adaptive Immunity through Cancer Vaccines

Journal of Immunology Research, 2017
Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically.
Elias J. Sayour, Duane A. Mitchell
doaj   +1 more source

Tumor infiltrating lymphocytes in glioblastoma: immunobiology and translational implications

npj Precision Oncology
Glioblastoma (GBM) poses unique challenges to immunotherapy, owing to its low tumor mutational burden, profound antigenic heterogeneity, and highly immunosuppressive microenvironment.
Cameron M. Hill, Chibueze D. Nwagwu, Angel O. Odukoya, Brian Hsueh, Anthony Z. Wang, Gavin P. Dunn   +5 more
doaj   +1 more source