Results 21 to 30 of about 643,956 (165)
Biomedicines, 2022 Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs ...
Simranjit X. Singh +8 more
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Lin−CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade
Nature Communications, 2018 Brain tumors are difficult to treat using existing immunotherapeutic strategies. Here, the authors show that in brain tumors resistant to PD-1 blockade, HSCs expressing CCR2+ can reverse treatment resistance and sensitizes mice to immunotherapy.
Catherine T. Flores +6 more
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Clinical evaluation of a dedicated next generation sequencing panel for routine glioma diagnostics
Acta Neuropathologica Communications, 2018 Since 2013 next-generation sequencing (NGS) targeting genes mutated in diffuse gliomas is part of routine diagnostics in our institute. In the present report, we evaluate the use of this custom tailored NGS platform on 434 samples. The NGS panel assesses
Nathalie E. Synhaeve +8 more
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Aquaporins and Brain Tumors [PDF]
International Journal of Molecular Sciences, 2016 Brain primary tumors are among the most diverse and complex human cancers, and they are normally classified on the basis of the cell-type and/or the grade of malignancy (the most malignant being glioblastoma multiforme (GBM), grade IV). Glioma cells are able to migrate throughout the brain and to stimulate angiogenesis, by inducing brain capillary ...
Rosario Maugeri +5 more
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Acta Oncologica, 1996 This synthesis of the literature on radiotherapy for brain tumors, ie, cancer originating in the central nervous system (CNS), is based on 81 scientific articles, including 25 randomized studies, 13 prospective studies, and 25 retrospective studies. These studies involve 11,081 patients.
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Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Nature Communications, 2017 Meningiomas are mostly benign brain tumours with the potential for becoming atypical or malignant. Here, the authors show that primary atypical meningiomas are epigenetically and genetically distinct from benign and progressed tumours, highlighting ...
Akdes Serin Harmancı +26 more
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Malignant Progression Contributes to the Failure of Combination Therapy for Atypical Meningiomas
Frontiers in Oncology, 2021 ObjectiveTo investigate the independent risk factors for recurrence in intracranial atypical meningiomas (AMs) treated with gross total resection (GTR) and early external beam radiotherapy (EBRT).MethodsClinical, radiological, and pathological data of ...
Qing Zhang +40 more
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Autonomic modulation of the immune response and implications for CNS malignancies
npj Precision OncologyWhile the central nervous system (CNS) has long been known to regulate global physiologic processes, its role in regulating immune responses has only relatively recently been appreciated.
Lucas P. Wachsmuth +5 more
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Frontiers in Oncology, 2020 BackgroundThis study was designed to explore the progression patterns of IDH-wildtype glioblastoma (GBM) at first recurrence after chemoradiotherapy.MethodsRecords from 247 patients who underwent progression after diagnosis of IDH-wildtype GBM was ...
Haihui Jiang +14 more
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