Results 151 to 160 of about 1,519,343 (314)

Advanced Launch System (ALS): Electrical actuation and power systems improve operability and cost picture [PDF]

To obtain the Advanced Launch System (ALS) primary goals of reduced costs and improved operability, there must be significant reductions in the launch operations and servicing requirements relative to current vehicle designs and practices.
Sundberg, Gale R.
core   +1 more source

PEDOT:PSS—A Key Material for Bioelectronics

Advanced Science, EarlyView.
PEDOT:PSS ‐ Poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate ‐ is typically processed from water dispersions to form multifunctional and multidimensional constructs with tunable electronic and ionic conductivity. Throught processing engineering, PEDOT:PSS is intergrated in bioelectronic devices that operate efficiently in physiological conditions
Alan Eduardo Ávila Ramírez, David Pieter van der Laan, Mustafeez Bashir Shah, Liwen Wang, Erica Zeglio, Achilleas Savva   +5 more
wiley   +1 more source

Single‐Target Pairing System (StarPair) for Large‐Scale Interrogation of Cell–Cell Interactions

Advanced Science, EarlyView.
This work presents a single‐target pairing system, StarPair, enabling cell–cell interaction studies by target combination in droplets. StarPair offers superior pairing efficiencies over 95% and operation frequencies of 105 pairs per 9.5 h for two‐target pairing, allowing large‐scale interrogation of immune cell‐cancer cell interactions and precise ...
Tianjiao Mao, Lang Nan, Miao Xu, Kehao Zeng, Yuchao Wang, Ziyu Han, Ho Cheung Shum   +6 more
wiley   +1 more source

Nusinersen for children with type I spinal muscular atrophy: 4 years’ clinical experience in Turkish cohort

Frontiers in Neurology
BackgroundSMA Type 1 is the most severe form of spinal muscular atrophy with early symptom onset, limited motor development, and poor prognosis. Recent genetic-based therapies, such as nusinersen, have transformed disease outcomes.
Ömer Bektaş, Murat Gülşen, Onur Burak Dursun, Ahmet Tekin, Deniz Yüksel, Ercan Demir, Gülten Öztürk, Sema Saltık, Özlem Hergüler, Ayşe Aysima Özçelik, Hüseyin Tan, Bilge Özgör, Arzu Ekici, Merve Feyza Yüksel, Süleyman Şahin, Özgür Duman, Mustafa Kömür, Figen Baydan, Edibe Pembegül Yıldız, Bülent Kara, Uluç Yiş, Seda Kanmaz, Kürşat Bora Çarman, Elif Acar Arslan, Mehmet Canpolat, Ahmet Sami Güven, Gökçen Öztuncer, Aycan Ünalp, Didem Ardıçlı, Aynur Ayşe Karaduman, Gökmen Zararsız, Gülhis Deda, Turkish SMA Study Group, Ömer Bektaş, Murat Gülşen, Onur Burak Dursun, Ahmet Tekin, Deniz Yüksel, Ercan Demir, Gülten Öztürk, Sema Saltık, Özlem Hergüler, Ayşe Aysima Özçelik, Hüseyin Tan, Bilge Özgör, Arzu Ekici, Merve Feyza Yüksel, Süleyman Şahin, Özgür Duman, Mustafa Kömür, Figen Baydan, Edibe Pembegül Yıldız, Bülent Kara, Uluç Yiş, Seda Kanmaz, Kürşat Bora Çarman, Elif Acar Arslan, Mehmet Canpolat, Ahmet Sami Güven, Gökçen Öztuncer, Aycan Ünalp, Didem Ardıçlı, Aynur Ayşe Karaduman, Gökmen Zararsız, Nurşah Yeniay Süt, Olcay Ünver, Tuğçe Damla Dilek, Eif Yıldırım, Faruk İncecik, Meral Karadağ, Mehmet Fatih Bütün, Burçin Gönüllü Polat, Yiğithan Güzin, Mehmet Akif Kılıç, Adnan Deniz, Gamze Sarıkaya Uzan, Sanem Yılmaz Keskin, Fatih M. Özdemir, Coşkun Yarar, Nihal Yıldız, Hamit Acer, Hüseyin Çaksen, Seren Aydın, Pakize Karaoğlu, Ayşe Neşe Çıtak, Tanıl Kendirli, Birkan Sonel Tur, Gülcan Akyüz, Ceren Bibinoğlu Amirov, Gülen Gül Mert, Mahmut Aslan, Şenay Haspolat, Özlem Ersoy, Osman Kipoğlu, Defne Alikılıç, Hasan Tekgül, Ülkühan Kaya, Arife Derda Yücel Şen, Pınar Özkan Kart, Hüseyin Per, Ayşe Aksoy, Ünsal Yılmaz, Serap Teber, Özben Akıncı Göktaş, Dilşad Türkdoğan, Fitnat Uluğ, Serap Bilge, Orhan Coşkun, Merve Öztürk, Esra Atmaca, Ali Cansu, Hakan Gümüş, Evrim Karadağ Saygı, Ömer Karaca, Serdal Güngör, Nazan Çobanoğlu, Melek Sezgin, Miraç Yıldırım, Yasemin Gökdemir, Esma Şengenç, Yılmaz Zindar, Özlem Yayıcı, Serkan Köken, Mesut Güngör, Serkan Kırık, Meltem Çobanoğulları Direk, Gülhis Deda   +126 more
doaj   +1 more source

A case presenting with delayed motor milestones

Neuromuscular Disorders, 2005
Muntoni, F, Zafeiriou, DI, Jimenez, C, Reuser, Arnold, Sewry, C   +4 more
openaire   +4 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Quantifying the Spectrum of Early Motor and Language Milestones in Sex Chromosome Trisomy

Pediatrics
BACKGROUND AND OBJECTIVES Sex chromosome trisomy (SCT) is a common chromosomal abnormality associated with increased risks for early developmental delays and neurodevelopmental disorders later in childhood. Our objective was to quantify the spectrum of early developmental milestones in SCT.
Talia Thompson, Samantha Bothwell, Jennifer Janusz, Rebecca Wilson, Susan Howell, Shanlee Davis, Karli Swenson, Sydney Martin, Karen Kowal, Chijioke Ikomi, Maria Despradel, Judith Ross, Nicole Tartaglia   +12 more
openaire   +2 more sources

Relationship between early motor milestones and severity of restricted and repetitive behaviors in children and adolescents with autism spectrum disorder

Autism Research, 2017
M. Uljarević, D. Hedley, G. Alvares, Kandice J. Varcin, A. Whitehouse   +4 more
semanticscholar   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source