Results 121 to 130 of about 207,929 (286)

Modularity of action programs in normal and Down syndrome individual / Modularidade de programas de ação em indivíduos normais e portadores da síndrome de Down

Psicologia: Reflexão e Crítica, 2006
Motor skills are represented as abstract form by action programs that once formed constitutes modules that ease the demand of motor control in complex tasks.
Roberto Gimenez, Edison de Jesus Manoel, Luciano Basso   +2 more
doaj  

The first GCT camera for the Cherenkov Telescope Array

, 2015
The Gamma Cherenkov Telescope (GCT) is proposed to be part of the Small Size Telescope (SST) array of the Cherenkov Telescope Array (CTA). The GCT dual-mirror optical design allows the use of a compact camera of diameter roughly 0.4 m.
Allan, D., Armstrong, T., Ashton, T., Balzer, A., Berge, D., Bose, R., Brown, A. M., Buckley, J., Chadwick, P. M., Cooke, P., Cotter, G., Daniel, M. K., De Franco, A., Funk, S., Greenshaw, T., Hinton, J., Kraus, M., Lapington, J., Molyneux, P., Moore, P., Nolan, S., Okumura, A., Ross, D., Rulten, C., Schmoll, J., Schoorlemmer, H., Stephan, M., Sutcliffe, P., Tajima, H., Thornhill, J., Tibaldo, L., Varner, G., Watson, J., White, R., Zink, A.   +34 more
core  

An Integrated Neural Network-Event-Related Potentials Model of Temporal and Probability Context Effects on Event Categorization [PDF]

, 1992
We present a neural network that adapts and integrates several preexisting or new modules to categorize events in short term memory (STM), encode temporal order in working memory, evaluate timing and probability context in medium and long term memory ...
Banquet, Jean-Paul, Contreras-Vidal, José L.   +1 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Design of a patient-tailored active knee-ankle-foot orthosis to assist the gait of spinal cord injured subjects [PDF]

, 2014
—This paper presents the main design steps in the development of an active knee-ankle-foot orthosis (KAFO) conceived to assist the gait of incomplete spinal cord injured (SCI) subjects.
Alonso, Francisco Javier, Clos Costa, Daniel, Cuadrado Aranda, Javier, Font Llagunes, Josep Maria, Lugrís Armesto, Urbano, Romero, Francisco   +5 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

METHOD OF DETERMINING THE START TIME OF INDUCTION MOTORS IN THE CONTROL OF RESISTOR-THYRISTOR MODULES

Electrical engineering & Electromechanics, 2015
Purpose. An electric general-purpose drive with asynchronous motor is proposed. For motor control in stator and rotor, circuits used resistors and thyristors. These elements included together in various ways.
V.I. Lobov, K.V. Lobova
doaj