Results 131 to 140 of about 1,460,414 (293)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Control And Monitoring Of Controller Area Network Based Motor And Sensor Boards

Gazi Üniversitesi Fen Bilimleri Dergisi, 2018
Remote control system also can use to provide the control of devices that are used in industrial environments nowadays. In this study, three experimental modules and one master module have been developed by using Arduino development board.
Kubilay Taşdelen, Mehmet Ali Şimşek, Ahmet Günaydın, Ecir Uğur Küçüksille   +3 more
doaj  

Rectified Latent Variable Model-Based EMG Factorization of Inhibitory Muscle Synergy Components Related to Aging, Expertise and Force–Tempo Variations

Sensors
Muscle synergy has been widely acknowledged as a possible strategy of neuromotor control, but current research has ignored the potential inhibitory components in muscle synergies.
Subing Huang, Xiaoyu Guo, Jodie J. Xie, Kelvin Y. S. Lau, Richard Liu, Arthur D. P. Mak, Vincent C. K. Cheung, Rosa H. M. Chan   +7 more
doaj   +1 more source

Detailed statement of motor vehicle registrations (in dollars)

, 2000
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Muscle synergies and metabolic adaptations during perturbed walking in older adults

Scientific Reports
Walking is an accessible and beneficial form of physical activity for older adults. However, when performed under perturbed conditions, it can place greater demands on both neuromuscular control and metabolic efficiency, highlighting the need to better ...
Samuel D’Emanuele, Marco Ghislieri, Laura Ghiotto, Francesca Morra, Lorenzo Budel, Doriana Rudi, Simone Bettega, Gennaro Boccia, Federico Schena, Cantor Tarperi   +9 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Review of Thermal Design of SiC Power Module for Motor Drive in Electrical Vehicle Application

CES Transactions on Electrical Machines and Systems
In the current vehicle electric propulsion systems, the thermal design of power modules heavily relies on empirical knowledge, making it challenging to effectively optimize irregularly arranged Pinfin structures, thereby limiting their performance.
Puqi Ning, Xiaoshuang Hui, Dongrun Li, Yuhui Kang, Jiajun Yang, Chaohui Liu   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Subliminal priming modulates motor sequence learning

Memory & Cognition
Abstract Sequential behaviour is underpinned by the selection and inhibition of movement at appropriate points in space and time. Sequences embedded among movement patterns must be learnt, yet the contribution of response selection and inhibition to the acquisition of motor sequences remains poorly understood.
Michael William Simpson, Jing Wu, Zheng Ye   +2 more
openaire   +2 more sources