Results 51 to 60 of about 207,929 (286)

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Frequency-specific intermuscular coherence of synergistic muscles during an isometric force generation task

Frontiers in Neural Circuits
IntroductionMotor tasks require the flexible selection and coordination of multiple muscles, which may be achieved through the organization and combination of muscle synergies.
Daniele Borzelli, Daniele Borzelli, Alberto Cacciola, Alberto Cacciola, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci, Carlo Vittorio Cannistraci, Angelo Alito, Demetrio Milardi, Andrea d’Avella, Andrea d’Avella   +10 more
doaj   +1 more source

Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Microbiology Spectrum, 2022
The type IX secretion system (T9SS) transports cargo proteins through the outer membrane of Bacteroidetes and attaches them to the cell surface for functions including pathogenesis, gliding motility, and degradation of carbon sources.
Dhana G. Gorasia, Ignacio Lunar Silva, Catherine A. Butler, Maïalène Chabalier, Thierry Doan, Eric Cascales, Paul D. Veith, Eric C. Reynolds   +7 more
doaj   +1 more source

Design and optimal springs stiffness estimation of a Modular OmniCrawler in-pipe climbing Robot

, 2017
This paper discusses the design of a novel compliant in-pipe climbing modular robot for small diameter pipes. The robot consists of a kinematic chain of 3 OmniCrawler modules with a link connected in between 2 adjacent modules via compliant joints. While
Krishna, K. Madhava, Sachdeva, Enna, Sarkar, Abhishek, Singh, Akash   +3 more
core   +1 more source

FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch. [PDF]

, 2018
Human speech is one of the few examples of vocal learning among mammals yet ~half of avian species exhibit this ability. Its neurogenetic basis is largely unknown beyond a shared requirement for FoxP2 in both humans and zebra finches.
Aamodt, Caitlin M, Burkett, Zachary Daniel, Day, Nancy F, Heston, Jonathan B, Hilliard, Austin T, Kimball, Todd Haswell, White, Stephanie A, Xiao, Xinshu   +7 more
core   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Fault-Tolerant Control of Modular Permanent Magnet Synchronous Motor Under Open-Circuit Faults

IEEE Access, 2019
The paper studies a novel fault-tolerant strategy of the modular permanent magnet synchronous motor under open-circuit faults, which is called as the extended open-circuit fault-tolerant control (EOCFTC) strategy.
Feng Chai, Lixiao Gao, Yanjun Yu, Yiping Liu   +3 more
doaj   +1 more source

Dissecting the genetic basis of comorbid epilepsy phenotypes in neurodevelopmental disorders. [PDF]

, 2019
BACKGROUND:Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, and motor ...
Amini, Hajar, Chow, Julie, Girirajan, Santhosh, Hormozdiari, Farhad, Hormozdiari, Fereydoun, Jensen, Matthew, Penn, Osnat, Shifman, Sagiv   +7 more
core  

Motor Domain Phosphorylation Modulates Kinesin-1 Transport [PDF]

Journal of Biological Chemistry, 2013
Disruptions in microtubule motor transport are associated with a variety of neurodegenerative diseases. Post-translational modification of the cargo-binding domain of the light and heavy chains of kinesin has been shown to regulate transport, but less is known about how modifications of the motor domain affect transport.
Hannah A, DeBerg, Benjamin H, Blehm, Janet, Sheung, Andrew R, Thompson, Carol S, Bookwalter, Seyed F, Torabi, Trina A, Schroer, Christopher L, Berger, Yi, Lu, Kathleen M, Trybus, Paul R, Selvin   +10 more
openaire   +2 more sources