Results 71 to 80 of about 207,929 (286)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Modulation of corticospinal excitability and muscle synergies during visuomotor locomotor task in individuals with and without cerebral palsy: a TMS and EMG study

Frontiers in Neurology
IntroductionStudies using transcranial magnetic stimulation and electromyography suggest that disrupted functional corticospinal connectivity significantly contributes to difficulty in initiating and controlling voluntary movements such as walking.
Yosra Cherni, Yosra Cherni, Marco Ghislieri, Marco Ghislieri, Laurent Bouyer, Laurent Bouyer, Catherine Mercier, Catherine Mercier   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Distinct Motor Modules After Anterior Cruciate Ligament Reconstruction During Stair Descent: A One-Year Longitudinal Study

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Anterior cruciate ligament (ACL) injury often leads to lasting deficits in joint stability and neuromuscular control, even after reconstruction. Understanding how these deficits manifest during functional tasks is essential for improving rehabilitation ...
Ye Wei, Zhifeng Zhou, Tianle Jie, Yi Yuan, Huiyu Zhou, Xiangli Gao, Tianxiao Chen, Qincheng Ge, Liangliang Xiang, Datao Xu, Yaodong Gu   +10 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Psychosocial Modulators of Motor Learning in Parkinson’s Disease [PDF]

Frontiers in Human Neuroscience, 2016
Using the remarkable overlap between brain circuits affected in Parkinson's disease (PD) and those underlying motor sequence learning, we may improve the effectiveness of motor rehabilitation interventions by identifying motor learning facilitators in PD.
Petra eZemankova, Petra eZemankova, Ovidiu eLungu, Martin eBares, Martin eBares, Martin eBares   +5 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Five-Axis Machine Tool Condition Monitoring Using dSPACE Real-Time System [PDF]

, 2012
This paper presents the design, development and SIMULINK implementation of the lumped parameter model of C-axis drive from GEISS five-axis CNC machine tool.
Fletcher, Simon, Longstaff, Andrew P., Myers, Alan, Pislaru, Crinela, Sztendel, S.   +4 more
core   +1 more source

Motor Recovery After Subcortical Stroke Depends on Modulation of Extant Motor Networks [PDF]

Frontiers in Neurology, 2015
Stroke is the leading cause of long-term disability. Functional imaging studies report widespread changes in movement-related cortical networks after stroke. Whether these are a result of stroke-specific cognitive processes or reflect modulation of existing movement-related networks is unknown. Understanding this distinction is critical in establishing
Sharma, N, Baron, J-C
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source