Results 271 to 280 of about 305,411 (311)

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

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Motor neural networks in the leech

Trends in Neurosciences, 2023
Leeches display robust motor patterns and exhibit a relatively simple nervous system where neurons are unambiguously identified. This brief article focuses on Hirudo verbana and summarizes how research in this organism has contributed to insights in the field of motor control, where networks have been studied from population down to individual neuron ...
openaire   +3 more sources

Kinesin’s Network of Chemomechanical Motor Cycles

Physical Review Letters, 2007
A general network theory for the molecular motor kinesin is developed that is based on the distinct chemical states of the motor and on recent observations about its mechanical steps. For small concentrations of adenosine diphosphate (ADP), the motor's behavior is governed by the competition of two chemomechanical motor cycles which determine the motor'
Liepelt, S., Lipowsky, R.
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Stabilization of motor networks

Proceedings of 1995 34th IEEE Conference on Decision and Control, 2002
In some cases the most important factor limiting the performance of a distributed control system is not the availability of computational power but rather the availablity of time on a shared communication network for communication between the sensors, the control computer and the actuators.
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Simulation of a molecular motor based communication network

Proceedings of the 1st international conference on Bio inspired models of network, information and computing systems - BIONETICS '06, 2006
Molecular communication provides a mechanism for the coordination and control of micro-scale and nano-scale devices. In this paper, we describe simulation models to evaluate a molecular communication system that uses molecular motors to transport information molecules over a filament network.
Michael J. Moore, Akihiro Enomoto, Tadashi Nakano, Tatsuya Suda, Atsushi Kayasuga, Hiroaki Kojima, Hitoshi Sakakibara, Kazuhiro Oiwa   +7 more
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Oscillation in motor pattern-generating networks

Current Opinion in Neurobiology, 1995
Oscillation in motor pattern generators is driven either by pacemaker neurons with inherent bursting properties or through network interactions. In a few examples in invertebrates and lower vertebrates, the mechanisms by which reciprocal inhibition combines with inherent membrane properties to produce network oscillation are beginning to emerge.
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Motor network structure and function are associated with motor performance in Huntington’s disease

Journal of Neurology, 2016
In Huntington's disease, the relationship of brain structure, brain function and clinical measures remains incompletely understood. We asked how sensory-motor network brain structure and neural activity relate to each other and to motor performance. Thirty-four early stage HD and 32 age- and sex-matched healthy control participants underwent structural
Hans-Peter, Müller, Martin, Gorges, Georg, Grön, Jan, Kassubek, G Bernhard, Landwehrmeyer, Sigurd D, Süßmuth, Robert Christian, Wolf, Michael, Orth   +7 more
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A structural motor network correlates with motor function and not impairment post stroke

Neuroscience Letters, 2017
Combining structural and functional magnetic resonance imaging may provide insight into how residual motor networks contribute to motor outcomes post-stroke. The purpose of this study was to examine whether a structural motor network (SMN), generated with fMRI guided diffusion-based tractography, relates to motor function post-stroke.
Peters, Sue, Wadden, Katie P., Hayward, Kathryn S., Neva, Jason L., Auriat, Angela M., Boyd, Lara A.   +5 more
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Plasticity in the Motor Network Following Primary Motor Cortex Lesion

2013
The behavioral deficits following stroke are particularly evident in the fine control of force, movement, and posture of the arm and hand. However, functional recovery continues in the weeks and months after the initial lesion. Various animal models of stroke have been used to investigate the mechanisms involved with this recovery.
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