Results 91 to 100 of about 390,159 (364)
Longitudinal imaging in C9orf72 mutation carriers: Relationship to phenotype
NeuroImage: Clinical, 2016 Expansion mutations in the C9orf72 gene may cause amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), or mixtures of the two clinical phenotypes. Different imaging findings have been described for C9orf72-associated diseases in comparison
Mary Kay Floeter +5 more
doaj +1 more source
Frontostriatal deficit in Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS) [PDF]
, 2003 So far, cognitive derangements in MND/ALS have not been widely studied. Nevertheless, it seems that in subgroups of patients cognitive functions are impaired in different degree, so that often at least two sub-types of the syndrome are reported: Motor ...
Bongioanni, Dr. P +4 more
core
Neuronal Development: Putting Motor Neurons in Their Place [PDF]
Current Biology, 2004 In the developing spinal cord, motor neurons occupy discrete columns with different identities and axon projections. This organisation has now been shown to depend crucially on sequential phases of expression of Hox-c proteins, generated in response to fibroblast growth factor signals.
openaire +4 more sources
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
Implementasi Kontroler Neural Fuzzy Pada Pengaturan Kecepatan Motor Induksi 3 Fasa [PDF]
, 2010 Motor induksi 3 fasa adalah alat penggerak yang paling banyak digunakan dalam dunia industri. Salah satuaplikasi motor induksi pada industri gula adalah pada mesin sentrifugal yang digunakan pada prosessentrifugasi.
Fauziyah, M. (Mila) +1 more
core
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA
EMBO Molecular Medicine, 2013 Two motor neuron diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are caused by distinct genes involved in RNA metabolism, TDP‐43 and FUS/TLS, and SMN, respectively.
Hitomi Tsuiji +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD
Frontiers in Neuroscience, 2019 Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics. Although the pathological mechanisms behind these diseases remain unclear, both ALS and
Thomas J. Hedl +11 more
doaj +1 more source
Neurons, Networks, and Motor Behavior [PDF]
Neuron, 1996 The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produce behaviors.
openaire +2 more sources