Results 101 to 110 of about 2,351,931 (407)
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Molecular NeurodegenerationBackground Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects the motor neurons, causing progressive muscle weakness and paralysis.
Natalie Grima +9 more
doaj +1 more source
Glial Cells in Amyotrophic Lateral Sclerosis
Neurology Research International, 2011 Amyotrophic lateral sclerosis (ALS) is an adult motor neuron disease characterized by premature death of upper and lower motor neurons. Two percent of ALS cases are caused by the dominant mutations in the gene for superoxide dismutase 1 (SOD1) through a ...
Jurate Lasiene, Koji Yamanaka
doaj +1 more source
Trials, 2023 Background MND-SMART is a platform, multi-arm, multi-stage, multi-centre, randomised controlled trial recruiting people with motor neuron disease.
Richard A. Parker +9 more
doaj +1 more source
Intraperitoneal Injection of Neonatal Mice
Bio-Protocol, 2023 Administration of substances into neonatal mice is required for early treatment with pre-clinical therapeutics, delivery of recombination-inducing substances, and dosing with viruses or toxins, amongst other things.
Amanda Pocratsky, James Sleigh
doaj +1 more source
Advances in motor neurone disease [PDF]
Journal of the Royal Society of Medicine, 2014 Summary Motor neurone disease (MND), the commonest clinical presentation of which is amyotrophic lateral sclerosis (ALS), is regarded as the most devastating of adult-onset neurodegenerative disorders. The last decade has seen major improvements in patient care, but also rapid scientific advances, so that rational therapies based on key pathogenic ...
Bäumer, D, Talbot, K, Turner, M
openaire +2 more sources
Motor Band Sign in Motor Neuron Disease: A Marker for Upper Motor Neuron Involvement
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2022 ABSTRACT:Background and Objective:The prevalence and role of the motor band sign (MBS) remain unclear in motor neuron disease. We report the frequency of MBS in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS), its correlation with clinical upper motor neuron (UMN) signs, and prognostic value in ALS.Methods:We conducted a ...
Hee Sahng Chung +3 more
openaire +2 more sources
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
BMC Neurology, 2019 Background Treatment of spasticity poses a major challenge in amyotrophic lateral sclerosis (ALS) patient management. Delta-9-tetrahydrocannabinol (THC):cannabidiol (CBD) oromucosal spray (THC:CBD), approved for the treatment of spasticity in multiple ...
Thomas Meyer +7 more
doaj +1 more source
C9orf72-related disorders: expanding the clinical and genetic spectrum of neurodegenerative diseases [PDF]
, 2015 Neurodegenerative diseases represent a heterogeneous group of neurological conditions primarily involving dementia, motor neuron disease and movement disorders. They are mostly related to different pathophysiological processes, notably in family forms in
Oliveira, Acary Souza Bulle +2 more
core +3 more sources