Results 111 to 120 of about 2,351,931 (407)
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma
Frontiers in Immunology, 2018 Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia, and glaucoma, affect millions of people worldwide.
Reka P. Toth +2 more
doaj +1 more source
Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells
Molecular Brain, 2015 Human pluripotent stem cells (hPSCs) are being applied in regenerative medicine and for the in vitro modeling of human intractable disorders. In particular, neural cells derived from disease-specific human induced pluripotent stem cells (hiPSCs ...
D. Shimojo +13 more
semanticscholar +1 more source
Implementasi Kontroler Neural Fuzzy Pada Pengaturan Kecepatan Motor Induksi 3 Fasa [PDF]
, 2010 Motor induksi 3 fasa adalah alat penggerak yang paling banyak digunakan dalam dunia industri. Salah satuaplikasi motor induksi pada industri gula adalah pada mesin sentrifugal yang digunakan pada prosessentrifugasi.
Fauziyah, M. (Mila) +1 more
core
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis
Materials Today Bio, 2020 Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a progressive neurodegenerative disease that affects both upper and lower motor neurons, which results in loss of muscle control and eventual paralysis [1].
G.Y. Wang +4 more
doaj +1 more source
C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits
Annals of Neurology, 2015 How hexanucleotide (GGGGCC) repeat expansions in C9ORF72 cause amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain‐ and loss‐of‐function mechanisms have been proposed.
M. Koppers +11 more
semanticscholar +1 more source
Neuroimaging of motor neuron diseases [PDF]
Therapeutic Advances in Neurological Disorders, 2012 It is agreed that conventional magnetic resonance imaging (MRI) of the brain and spine is one of the core elements in the differential diagnostic work up of patients with clinical signs of motor neuron diseases (MNDs), for example amyotrophic lateral sclerosis (ALS), to exclude MND mimics. However, the sensitivity and specificity of MRI signs in these
Jan Kassubek +2 more
openaire +4 more sources
Letter to the editor: autoimmune pathogenic mechanisms in amyotrophic lateral sclerosis [PDF]
, 2018 The innate immune system may affect the function and survival of motor neurons in ALS by at least three mechanisms. First, there is evidence to suggest that aggregates of mutant SOD1—which is derived from microglial and astroglial cells—activate ...
de Vincentiis, M. +5 more
core +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source