Results 131 to 140 of about 2,351,931 (407)
Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis
Cell Death and Differentiation, 2021 Taide Wang +12 more
semanticscholar +1 more source
Imperial strategy of cancer cells through mitochondrial transfer
Molecular Oncology, EarlyView.Cangkrama et al. demonstrated that cancer cells donate their mitochondria to fibroblasts through mitochondrial transfer, reprogramming them into ‘MitoCAF’. Likewise, our group has identified mitochondrial transfer from cancer cells to tumor infiltrating lymphocytes, resulting in mitochondrial ‘hijack’ and impaired antitumor immunity.
Takamasa Ishino, Yosuke Togashi
wiley +1 more source
A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications
Molecular Oncology, EarlyView.Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker +3 more
wiley +1 more source
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA
EMBO Molecular Medicine, 2013 Two motor neuron diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are caused by distinct genes involved in RNA metabolism, TDP‐43 and FUS/TLS, and SMN, respectively.
Hitomi Tsuiji +11 more
doaj +1 more source
Neurons, Networks, and Motor Behavior [PDF]
Neuron, 1996 The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produce behaviors.
openaire +2 more sources
UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy [PDF]
, 2018 Deafferentation of motor neurons as a result of defective sensory-motor connectivity is a critical early event in the pathogenesis of spinal muscular atrophy, but the underlying molecular pathways remain unknown.
Boyd, Penelope J. +10 more
core +3 more sources
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD
Frontiers in Neuroscience, 2019 Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics. Although the pathological mechanisms behind these diseases remain unclear, both ALS and
Thomas J. Hedl +11 more
doaj +1 more source
Specifiying Motor Neurons and their Connections [PDF]
Neuron, 1998 The two papers described above provide important insights into two steps in the differentiation program of motor neurons. Motor neurons are the primary efferent class of neurons in the spinal cord and are an essential component of locomotor circuits in the spinal cord.
openaire +3 more sources
Effects of Nicotine on Embryological Neural Development [PDF]
, 2007 1st Place in Denman Undergraduate Research ForumOver 1 million women, approximately 12-22% of the U.S. population, smoke while pregnant (Centers for Disease Control).
Subbarao, Tara
core