Results 51 to 60 of about 2,351,931 (407)
EMBO Journal, 2016 FUS is an RNA‐binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS‐containing aggregates are often associated with concomitant loss of nuclear FUS.
Jelena Scekic-Zahirovic +23 more
semanticscholar +1 more source
Inter-spikes-intervals exponential and gamma distributions study of neuron firing rate for SVITE motor control model on FPGA [PDF]
, 2015 This paper presents a statistical study on a neuro-inspired spike-based implementation of the Vector-Integration-To-End-Point motor controller (SVITE) and compares its deterministic neuron-model stream of spikes with a proposed modification that converts
Linares Barranco, Alejandro +2 more
core +1 more source
Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis
Acta Neuropathologica, 2017 In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate.
Jik Nijssen, L. Comley, E. Hedlund
semanticscholar +1 more source
Occasional essay: upper motor neuron syndrome in amyotrophic lateral sclerosis [PDF]
, 2020 The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected ...
Burke, David +6 more
core +1 more source
Cell Reports, 2013 Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by a deficiency in the survival motor neuron (SMN) protein. SMN mediates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs) and possibly other RNPs.
Sarah Tisdale +7 more
doaj +1 more source
Journal of Neuroscience, 2016 Spinal muscular atrophy (SMA) is a neurodegenerative disease primarily affecting spinal motor neurons. It is caused by reduced levels of the survival of motor neuron (SMN) protein, which plays an essential role in the biogenesis of spliceosomal small ...
C. Fallini +4 more
semanticscholar +1 more source
Postgraduate Medical Journal, 1962 THE story of motor neurone disease goes back more than a hundred years, to the latter half of the igth century, and the days of the great clinical neurologists of France. Of the many famous names linked to this story three are pre-eminent: Charcot-physician and neuropathologist, and great teacher, who became even more renowned for his studies of ...
openaire +3 more sources
Motor Learning Mechanism on the Neuron Scale
, 2014 Based on existing data, we wish to put forward a biological model of motor system on the neuron scale. Then we indicate its implications in statistics and learning.
Liu, Peilei, Wang, Ting
core +1 more source
Lower Motor Neuron Weakness After Diving-Related Decompression [PDF]
, 2006 We present a case of lower motor neuron upper limb weakness due to infarction of the anterior horn cells of the spinal cord following diving. To our knowledge, this is the first report of an isolated lower motor neuron syndrome following diving-related ...
Henderson, Robert D., Pender, Michael P.
core +2 more sources
Inflammation in ALS and SMA: Sorting out the good from the evil
Neurobiology of Disease, 2010 Indices of neuroinflammation are found in a variety of diseases of the CNS including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).
Dimitra Papadimitriou +5 more
doaj +1 more source