Results 211 to 220 of about 423,991 (315)

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

Mapping the Evidence for Measuring Energy Expenditure and Indicating Hypermetabolism in Motor Neuron Disease: A Scoping Review. [PDF]

Nutr Rev
Roscoe SA, Allen SP, McDermott CJ, Stavroulakis T.   +3 more
europepmc   +1 more source

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition [PDF]

, 2008
Jan Hauke, Markus Rießland, Sebastian Lunke, Ilker Y. Eyüpoglu, Ingmar Blümcke, Assam El‐Osta, Brunhilde Wirth, Eric Hahnen   +7 more
openalex   +1 more source

TDP‐43 A315T mutation in familial motor neuron disease

Annals of Neurology, 2008
M. Gitcho, R. Baloh, S. Chakraverty, K. Mayo, J. Norton, D. Levitch, K. Hatanpaa, C. White, E. Bigio, R. Caselli, M. Baker, M. Al-Lozi, J. Morris, A. Pestronk, R. Rademakers, A. Goate, N. Cairns   +16 more
semanticscholar   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Chaperone dysfunction in motor neuron disease: new insights from studies of the SMN complex. [PDF]

Genetics
Matera AG.
europepmc   +1 more source

Beyond Order: Perspectives on Leveraging Machine Learning for Disordered Materials

Advanced Engineering Materials, EarlyView.
This article explores how machine learning (ML) revolutionizes the study and design of disordered materials by uncovering hidden patterns, predicting properties, and optimizing multiscale structures. It highlights key advancements, including generative models, graph neural networks, and hybrid ML‐physics methods, addressing challenges like data ...
Hamidreza Yazdani Sarvestani, Surabhi Nadigotti, Erfan Fatehi, Derek Aranguren van Egmond, Behnam Ashrafi   +4 more
wiley   +1 more source

Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron disease. [PDF]

EBioMedicine
Holdom CJ, Pilkar R, Guo CC, Eijk RPAV, Sethi N, Henderson RD, Ngo ST, Steyn FJ.   +7 more
europepmc   +1 more source

TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy

Journal of Neuropathology and Experimental Neurology, 2010
A. Mckee, B. Gavett, R. Stern, Christopher J. Nowinski, R. Cantu, N. Kowall, D. Perl, E. Hedley‐Whyte, B. Price, C. Sullivan, P. Morin, Hyo-Soon Lee, Caroline A. Kubilus, Daniel H. Daneshvar, Megan Wulff, A. Budson   +15 more
semanticscholar   +1 more source

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source