The role of the innate immune system in ALS
Frontiers in Pharmacology, 2012 ALS is a fatal, adult-onset neurodegenerative disease which is characterized by the death of upper and lower motor neurons. Recent studies have made clear that although motor neurons are the primary targets of the degenerative process, other cell types ...
Sudarshan ePhani +2 more
doaj +1 more source
A Human iPSC Line Carrying a de novo Pathogenic FUS Mutation Identified in a Patient With Juvenile ALS Differentiated Into Motor Neurons With Pathological Characteristics [PDF]
, 2020 Li Chen, Yali Wang, Jie Xie
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Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons [PDF]
, 2022 Banaja P. Dash +3 more
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TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]
, 1997 Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Cell Transplantation, 2013 Amyotrophic lateral sclerosis (ALS) is a fatal disease that involves the degeneration of cortical and spinal motor neurons. Mutant SOD1 G93A rats constitute a good animal model for this pathological condition.
Ying Li +9 more
doaj +1 more source
Impact of the metabolic syndrome on prevalence and survival in motor neuron disease: a retrospective case series [PDF]
, 2023 Jee Eun Oh +4 more
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Noninvasive ¹³C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis [PDF]
, 1999 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons. However, ALS has been recognized to also involve non-motor systems.
Folwaczny, Christian +6 more
core +1 more source
Neural Representations of Courtship Song in the Drosophila Brain [PDF]
, 2012 Acoustic communication in drosophilid flies is based on the production and perception of courtship songs, which facilitate mating. Despite decades of research on courtship songs and behavior in Drosophila, central auditory responses have remained ...
, +4 more
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